Shih Kun-Yauh, Yu Shiou-Ching
Department of Applied Chemistry, National Pingtung University, Pingtung County 90003, Taiwan.
Materials (Basel). 2021 Dec 22;15(1):43. doi: 10.3390/ma15010043.
Nanomaterials with high antibacterial activity and low cytotoxicity have attracted extensive attention from scientists. In this study, europium (III) hydroxide (Eu(OH))/reduced graphene oxide (RGO) nanocomposites were synthesized using a rapid, one-step method, and their antibacterial activity against () was investigated using the synergistic effect of the antibacterial activity between Eu and graphene oxide (GO). The Eu(OH)/RGO nanocomposites were prepared using a microwave-assisted synthesis method and characterized using X-ray diffraction, scanning electron microscopy, photoluminescence spectroscopy, Raman spectroscopy, and Fourier-transform infrared spectroscopy. Raman sprectroscopy and X-ray diffraction confirmed the pure hexagonal phase structure of the nanocomposites. Further, the antibacterial properties of Eu(OH)/RGO were investigated using the minimum inhibitory concentration assay, colony counting method, inhibition zone diameter, and optical density measurements. The results revealed that the Eu(OH)/RGO exhibited a superior inhibition effect against and a larger inhibition zone diameter compared to RGO and Eu(OH). Further, the reusability test revealed that Eu(OH)/RGO nanocomposite retained above 98% of its bacterial inhibition effect after seven consecutive applications. The high antibacterial activity of the Eu(OH)/RGO nanocomposite could be attributed to the release of Eu ions from the nanocomposite and the sharp edge of RGO. These results indicated the potential bactericidal applications of the Eu(OH)/RGO nanocomposite.
具有高抗菌活性和低细胞毒性的纳米材料引起了科学家们的广泛关注。在本研究中，采用快速一步法合成了氢氧化铕（Eu(OH)）/还原氧化石墨烯（RGO）纳米复合材料，并利用Eu与氧化石墨烯（GO）之间抗菌活性的协同效应研究了它们对（此处原文括号内容缺失）的抗菌活性。采用微波辅助合成法制备了Eu(OH)/RGO纳米复合材料，并通过X射线衍射、扫描电子显微镜、光致发光光谱、拉曼光谱和傅里叶变换红外光谱对其进行了表征。拉曼光谱和X射线衍射证实了纳米复合材料的纯六方相结构。此外，采用最低抑菌浓度测定法、菌落计数法、抑菌圈直径和光密度测量等方法研究了Eu(OH)/RGO的抗菌性能。结果表明，与RGO和Eu(OH)相比，Eu(OH)/RGO对（此处原文括号内容缺失）表现出优异的抑制效果和更大的抑菌圈直径。此外，可重复使用性测试表明，Eu(OH)/RGO纳米复合材料在连续应用七次后仍保留其细菌抑制效果的98%以上。Eu(OH)/RGO纳米复合材料的高抗菌活性可归因于纳米复合材料中Eu离子的释放以及RGO的尖锐边缘。这些结果表明了Eu(OH)/RGO纳米复合材料潜在的杀菌应用。
