BiOSENCY, 1137a Avenue des Champs Blancs, 35510 Cesson-Sévigné, France.
ORPHY, Université de Bretagne Occidentale, 6 Avenue Victor le Gorgeu, 29238 Brest, France.
Sensors (Basel). 2021 Dec 28;22(1):188. doi: 10.3390/s22010188.
Carbon dioxide (CO2) monitoring in human subjects is of crucial importance in medical practice. Transcutaneous monitors based on the Stow-Severinghaus electrode make a good alternative to the painful and risky arterial "blood gases" sampling. Yet, such monitors are not only expensive, but also bulky and continuously drifting, requiring frequent recalibrations by trained medical staff. Aiming at finding alternatives, the full panel of CO2 measurement techniques is thoroughly reviewed. The physicochemical working principle of each sensing technique is given, as well as some typical merit criteria, advantages, and drawbacks. An overview of the main CO2 monitoring methods and sites routinely used in clinical practice is also provided, revealing their constraints and specificities. The reviewed CO2 sensing techniques are then evaluated in view of the latter clinical constraints and transcutaneous sensing coupled to a dye-based fluorescence CO2 sensing seems to offer the best potential for the development of a future non-invasive clinical CO2 monitor.
在医学实践中，对人体二氧化碳（CO2）的监测至关重要。基于 Stow-Severinghaus 电极的经皮监测器是一种替代痛苦且有风险的动脉“血气”采样的良好方法。然而，此类监测器不仅昂贵，而且体积庞大且不断漂移，需要经过训练的医务人员频繁进行重新校准。为了寻找替代品，本文全面回顾了 CO2 测量技术的全部内容。介绍了每种传感技术的物理化学工作原理，以及一些典型的优点、标准、优点和缺点。还概述了临床实践中常用的主要 CO2 监测方法和部位，揭示了它们的局限性和特殊性。然后，根据后者的临床限制评估了所审查的 CO2 传感技术，结合基于染料的荧光 CO2 传感的经皮传感似乎为开发未来的非侵入性临床 CO2 监测器提供了最佳潜力。
