Department of Oral Medicine, Medical University of Lublin, ul. Chodźki 6, 20-093 Lublin, Poland.
Int J Environ Res Public Health. 2022 Jan 2;19(1):479. doi: 10.3390/ijerph19010479.
The oral cavity is the place where the first symptoms of systemic diseases may appear. Leukemia is the malignancy of the hematopoietic system in which abnormal leukocytes are produced in the bone marrow and these cells spread to the peripheral blood. It is classified clinically on the basis of the duration and nature of the disease (acute or chronic), the type of cell involved (myeloid, lymphoid, or monocytes), and a rise in the number of abnormal cells in the blood. The study aimed to assess and compare the oral hygiene and periodontium status based on the indices in leukemic patients before and after one cycle of chemotherapy and whether the therapy had an impact on the change of these parameters. Dental indices used in clinical diagnostics were calculated: API (approximal plaque index), SBI (sulcus bleeding index), and CPI (community periodontal index). The research project was conducted at the Clinic of Hematooncology and Bone Marrow Transplantation of the Independent Public Clinical Hospital No. 1 in Lublin. The target population consisted of 102 adults with leukemia who were over 18 years of age. The time since diagnosis of the disease ranged from 1 to 10 years. The data were evaluated in the Statistica 12 software with the respective tests. In the majority of patients, both before and after chemotherapy, improper oral hygiene and severe generalized periodontitis were confirmed. The cycle of chemotherapy that was used did not correlate with the change of patients' oral hygiene and periodontium state. Unsatisfactory oral hygiene and periodontal health has to be addressed with urgent dental treatment to avoid systemic complications in leukemic patients.
口腔是全身性疾病最初症状可能出现的部位。白血病是造血系统的恶性肿瘤，骨髓中产生异常白细胞，这些细胞扩散到外周血液中。它根据疾病的持续时间和性质（急性或慢性）、涉及的细胞类型（髓样、淋巴样或单核细胞）以及血液中异常细胞数量的增加进行临床分类。本研究旨在评估和比较白血病患者在接受一个化疗周期前后的口腔卫生和牙周状况，并评估该治疗方法是否会对这些参数的变化产生影响。在临床诊断中使用了以下牙科指数：API（近中菌斑指数）、SBI（龈沟出血指数）和 CPI（社区牙周指数）。该研究项目在卢布林独立公立临床医院 1 号血液肿瘤学和骨髓移植科进行。目标人群包括 102 名年龄在 18 岁以上的白血病成年人。从诊断疾病到现在的时间范围为 1 至 10 年。使用 Statistica 12 软件评估数据，并进行相应的测试。在大多数患者中，化疗前后均证实口腔卫生状况不佳和严重的广泛性牙周炎。所使用的化疗周期与患者口腔卫生和牙周状况的变化无关。必须对口腔卫生和牙周健康状况不佳的患者进行紧急牙科治疗，以避免白血病患者出现全身并发症。
