Schmalz Gerhard, Tulani Lulzim, Busjan Rilana, Haak Rainer, Kottmann Tanja, Trümper Lorenz, Hasenkamp Justin, Ziebolz Dirk
Dept. of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, Germany.
Clinical Research Organization, Hamm, Germany.
Adv Hematol. 2020 Apr 21;2020:6710906. doi: 10.1155/2020/6710906. eCollection 2020.
This retrospective pilot study aimed to detect whether remaining dental/periodontal treatment need and periodontal inflammation after dental clearance would be associated with the initial therapy outcome of adult patients with acute leukemia undergoing induction chemotherapy. Different parameters were assessed from the patients' records: initial blood parameters, blood parameters during initial chemotherapy, leukemia/therapy related complaints, duration of fever, microbiological findings (blood and urine), as well as patients' survival. Dental treatment need was defined as the presence of at least one carious tooth; periodontal treatment need was determined by the presence of probing depth ≥3.5 mm in at least two sextants. To reflect periodontal inflammation, the periodontal inflamed surface area (PISA) was applied. Thirty-nine patients were included. A dental treatment need of 75% and periodontal treatment need of 76% as well as an average PISA of 153.18 ± 158.09 were found. Only two associations were detected: periodontal treatment need was associated with thrombocyte count after 7 days (=0.03), and PISA was associated with erythrocyte count three days after induction of therapy (=0.01). It can be concluded that remaining dental and periodontal treatment need as well as periodontal inflammation after dental clearance is not associated with the outcome of induction therapy in adult patients with acute leukemia.
这项回顾性试点研究旨在检测成人急性白血病患者在诱导化疗后，剩余的牙齿/牙周治疗需求以及牙周炎症是否与初始治疗结果相关。从患者记录中评估了不同参数：初始血液参数、初始化疗期间的血液参数、白血病/治疗相关主诉、发热持续时间、微生物学检查结果（血液和尿液）以及患者生存率。牙齿治疗需求定义为至少有一颗龋齿；牙周治疗需求通过至少两个牙象限中探诊深度≥3.5毫米来确定。为反映牙周炎症，采用了牙周炎症表面积（PISA）。纳入了39名患者。发现牙齿治疗需求为75%，牙周治疗需求为76%，平均PISA为153.18±158.09。仅检测到两个关联：牙周治疗需求与7天后的血小板计数相关（=0.03），PISA与诱导治疗3天后的红细胞计数相关（=0.01）。可以得出结论，成人急性白血病患者在牙齿清理后剩余的牙齿和牙周治疗需求以及牙周炎症与诱导治疗结果无关。
