Agüero-Domenech Nuria, Jover Silvia, Sarrión Ana, Baranda Javier, Quesada-Rico José A, Pereira-Expósito Avelino, Gil-Guillén Vicente, Cortés-Castell Ernesto, García-Teruel María J
Department of Gynaecology and Obstetrics, Hospital General Universitario Elda, 03600 Elda, Spain.
Department of Public Health, History of Science and Gynaecology, Miguel Hernández University, 03550 San Juan, Spain.
Nutrients. 2021 Dec 27;14(1):102. doi: 10.3390/nu14010102.
A relationship between vitamin D deficiency (VDD) and gestational diabetes mellitus (GDM) has been described. Considering that GDM prevalence depends on body mass index (BMI), our main objective was to determine if VDD is associated with GDM, independent of BMI. A cross-sectional study with 886 pregnant women was conducted in Elda (Spain) from September 2019 to June 2020. To assess the association, Poisson regression models with robust variance were used to estimate the prevalence ratio (PR). The observed GDM prevalence was 10.5%, while the VDD prevalence was 55.5%. In the crude model, both VDD and obesity were associated with GDM, but in the adjusted model, only VDD was statistically significant (PR = 1.635, = 0.038). A secondary event analysis did not detect differences in VDD, but BMI yielded a higher frequency of births by cesarean section and newborns with a >90 percentile weight in the obesity group. In conclusion, VDD is associated with GDM, independent of BMI. Future longitudinal studies could provide information on causality.
维生素D缺乏（VDD）与妊娠期糖尿病（GDM）之间的关系已被描述。鉴于GDM的患病率取决于体重指数（BMI），我们的主要目标是确定VDD是否与GDM相关，而独立于BMI。2019年9月至2020年6月在西班牙埃尔达对886名孕妇进行了一项横断面研究。为了评估这种关联，使用具有稳健方差的泊松回归模型来估计患病率比（PR）。观察到的GDM患病率为10.5%，而VDD患病率为55.5%。在粗模型中，VDD和肥胖都与GDM相关，但在调整模型中，只有VDD具有统计学意义（PR = 1.635，P = 0.038）。一项次要事件分析未发现VDD存在差异，但BMI在肥胖组中导致剖宫产分娩和体重>第90百分位数新生儿的频率更高。总之，VDD与GDM相关，独立于BMI。未来的纵向研究可以提供因果关系方面的信息。
