红参提取物与特应性皮炎常规系统治疗在小鼠模型中的协同作用。
Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model.
机构信息
Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Villa de Skin, Hwaseong 18478, Korea.
出版信息
Nutrients. 2021 Dec 28;14(1):133. doi: 10.3390/nu14010133.
The synergistic effects of Korean Red ginseng (KRG, C.A. Mey.) on conventional systemic therapeutics of atopic dermatitis (AD) have not been studied yet. To analyze the synergistic effects of KRG extract and the conventional systemic therapeutics of AD in TNCB-induced AD mouse model, we determined the change in modified scoring of index, the transepidermal water loss, the skin pathology, serum IgE, and the expression of various cytokines after combination treatment to the five-week-old NC/Nga female mice. The severity of AD was significantly decreased in the KRG + hydroxyzine (AH) group than AH group, and in the KRG + evening primrose oil (EPO) group than EPO group. A significant decrease in dermal inflammation was observed in the KRG + AH group than that in the AH group, and in the KRG + EPO group than that in the EPO group ( = 0.008), respectively. A decrease in CD1a expression was observed in the KRG + AH group when compared to the AH group ( = 0.008), and KRG + EPO group when compared to the EPO group. Compared to the CS group, the KRG + CS group showed a significant decrease in IL-17 expression. A combination of KRG and conventional systemic therapeutics can safely and effectively manage the AD.
红参（KRG）对特应性皮炎（AD）的常规系统治疗的协同作用尚未得到研究。为了分析 KRG 提取物与 AD 的常规系统治疗在 TNCB 诱导的 AD 小鼠模型中的协同作用，我们测定了改良指数评分、经表皮水分流失、皮肤病理、血清 IgE 和各种细胞因子表达的变化，对 5 周龄 NC/Nga 雌性小鼠进行联合治疗。与 AH 组相比，KRG+羟嗪（AH）组的 AD 严重程度显著降低，与 EPO 组相比，KRG+月见草油（EPO）组的 AD 严重程度显著降低。与 AH 组相比，KRG+AH 组真皮炎症显著减少，与 EPO 组相比，KRG+EPO 组真皮炎症显著减少（ = 0.008）。与 AH 组相比，KRG+AH 组 CD1a 表达减少（ = 0.008），与 EPO 组相比，KRG+EPO 组 CD1a 表达减少。与 CS 组相比，KRG+CS 组 IL-17 表达显著降低。KRG 与常规系统疗法的联合使用可以安全有效地治疗 AD。
Zotero 插件