CD1a 在人类皮肤病中的作用。
CD1a function in human skin disease.
机构信息
Department of Dermatology, Columbia University Irving Medical Center, New York, NY, USA.
Medical Research Council Human Immunology Unit, Radcliffe Department of Medicine, Oxford National Institute for Health Research Biomedical Research Centre, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
出版信息
Mol Immunol. 2021 Feb;130:14-19. doi: 10.1016/j.molimm.2020.12.006. Epub 2020 Dec 18.
Abstract
The high expression of CD1a on Langerhans cells in normal human skin suggests a central role for this lipid antigen presenting molecule in skin homeostasis and immunity. Although the lipid antigen presenting function of CD1a has been known for years, the physiological and pathological functions of the CD1a system in human skin remain incompletely understood. This review provides an overview of this active area of investigation, and discusses recent insights into the functions of CD1a, CD1a-restricted T cells, and lipid antigens in inflammatory and allergic skin disease. We include recent publications and work presented at the biennial CD1-MR1 EMBO workshop held in 2019 in Oxford, regarding lipids that increase and those that decrease T cell responses to CD1a.
摘要
在正常人体皮肤中，朗格汉斯细胞上 CD1a 的高表达表明，这种脂质抗原呈递分子在皮肤稳态和免疫中起着核心作用。尽管 CD1a 的脂质抗原呈递功能已为人所知多年，但 CD1a 系统在人类皮肤中的生理和病理功能仍不完全清楚。这篇综述概述了这一活跃的研究领域，并讨论了 CD1a、CD1a 限制性 T 细胞和脂质抗原在炎症性和过敏性皮肤病中的功能的最新见解。我们包括了最近的出版物和在 2019 年于牛津举行的两年一次的 CD1-MR1 EMBO 研讨会上发表的关于增加和减少 CD1a 对 T 细胞反应的脂质的工作。
相似文献
1
CD1a function in human skin disease.CD1a 在人类皮肤病中的作用。
Mol Immunol. 2021 Feb;130:14-19. doi: 10.1016/j.molimm.2020.12.006. Epub 2020 Dec 18.
2
Epidermal Langerhans cells efficiently mediate CD1a-dependent presentation of microbial lipid antigens to T cells.表皮朗格汉斯细胞能有效地介导微生物脂质抗原依赖CD1a向T细胞的呈递。
J Invest Dermatol. 2003 Sep;121(3):517-21. doi: 10.1046/j.1523-1747.2003.12429.x.
3
CD1a and skin T cells: a pathway for therapeutic intervention.CD1a与皮肤T细胞：一种治疗干预途径
Clin Exp Dermatol. 2024 Apr 23;49(5):450-458. doi: 10.1093/ced/llad460.
4
CD1a-mediated immunity from a molecular perspective.从分子角度看 CD1a 介导的免疫。
Mol Immunol. 2023 Jun;158:43-53. doi: 10.1016/j.molimm.2023.04.010. Epub 2023 Apr 26.
5
Antigen Presentation by CD1 Lipids, T Cells, and NKT Cells in Microbial Immunity.CD1脂质、T细胞和NKT细胞在微生物免疫中的抗原呈递
Adv Immunol. 2009;102:1-94. doi: 10.1016/S0065-2776(09)01201-2.
6
CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens.CD1a 自身反应性 T 细胞识别作为无头抗原的天然皮肤油。
Nat Immunol. 2014 Feb;15(2):177-85. doi: 10.1038/ni.2790. Epub 2013 Dec 22.
7
Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.银屑病T细胞识别由肥大细胞磷脂酶产生、通过外泌体传递并由CD1a呈递的新脂质抗原。
J Exp Med. 2016 Oct 17;213(11):2399-2412. doi: 10.1084/jem.20160258. Epub 2016 Sep 26.
8
Animal models for human group 1 CD1 protein function.用于研究人类 CD1 蛋白功能的动物模型。
Mol Immunol. 2021 Feb;130:159-163. doi: 10.1016/j.molimm.2020.12.018. Epub 2020 Dec 29.
9
A potential role for CD1a molecules on human epidermal Langerhans cells in allogeneic T-cell activation.人类表皮朗格汉斯细胞上的CD1a分子在同种异体T细胞激活中的潜在作用。
J Invest Dermatol. 1991 Sep;97(3):524-8. doi: 10.1111/1523-1747.ep12481556.
10
Contact sensitizers trigger human CD1-autoreactive T-cell responses.接触性致敏原可引发人类CD1自身反应性T细胞应答。
Eur J Immunol. 2017 Jul;47(7):1171-1180. doi: 10.1002/eji.201746939. Epub 2017 May 23.
引用本文的文献
1
CD1a and Lipids as Mediators of T Cell Activation in the Skin.CD1a与脂质作为皮肤中T细胞活化的介质
J Invest Dermatol. 2025 May 3. doi: 10.1016/j.jid.2025.03.020.
2
Protein Haptenation and Its Role in Allergy.蛋白质半抗原化及其在过敏中的作用。
Chem Res Toxicol. 2024 Jun 17;37(6):850-872. doi: 10.1021/acs.chemrestox.4c00062. Epub 2024 Jun 4.
3
Integrated Analysis of CD1A Immune Infiltration and Competing Endogenous RNA Networks in COAD.结肠癌中CD1A免疫浸润与竞争性内源性RNA网络的综合分析
Int J Gen Med. 2024 May 11;17:2037-2053. doi: 10.2147/IJGM.S455546. eCollection 2024.
4
Functional and biological implications of clonotypic diversity among human donor-unrestricted T cells.人类供者非限制 T 细胞克隆多样性的功能和生物学意义。
Immunol Cell Biol. 2024 Jul;102(6):474-486. doi: 10.1111/imcb.12751. Epub 2024 Apr 24.
5
CD1a and skin T cells: a pathway for therapeutic intervention.CD1a与皮肤T细胞：一种治疗干预途径
Clin Exp Dermatol. 2024 Apr 23;49(5):450-458. doi: 10.1093/ced/llad460.
6
Can we predict T cell specificity with digital biology and machine learning?我们能否通过数字生物学和机器学习来预测 T 细胞特异性？
Nat Rev Immunol. 2023 Aug;23(8):511-521. doi: 10.1038/s41577-023-00835-3. Epub 2023 Feb 8.
7
Role of Group 1 CD1-Restricted T Cells in Host Defense and Inflammatory Diseases.CD1 限制性第 1 组 T 细胞在宿主防御和炎症性疾病中的作用。
Crit Rev Immunol. 2021;41(4):1-21. doi: 10.1615/CritRevImmunol.2021040089.
8
In Vitro Monitoring of Human T Cell Responses to Skin Sensitizing Chemicals-A Systematic Review.体外监测人类 T 细胞对皮肤致敏化学品的反应——系统评价。
Cells. 2021 Dec 28;11(1):83. doi: 10.3390/cells11010083.
9
Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model.红参提取物与特应性皮炎常规系统治疗在小鼠模型中的协同作用。
Nutrients. 2021 Dec 28;14(1):133. doi: 10.3390/nu14010133.
10
Does CD1a Expression Influence T Cell Function in Patients With Langerhans Cell Histiocytosis?CD1a 表达是否影响朗格汉斯细胞组织细胞增生症患者的 T 细胞功能？
Front Immunol. 2021 Dec 10;12:773598. doi: 10.3389/fimmu.2021.773598. eCollection 2021.
本文引用的文献
1
Human skin is colonized by T cells that recognize CD1a independently of lipid.人类皮肤被能够独立于脂质识别 CD1a 的 T 细胞定植。
J Clin Invest. 2021 Jan 4;131(1). doi: 10.1172/JCI140706.
2
Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis.胶带条在特应性皮炎和银屑病中检测到不同的免疫和屏障特征。
J Allergy Clin Immunol. 2021 Jan;147(1):199-212. doi: 10.1016/j.jaci.2020.05.048. Epub 2020 Jul 21.
3
Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products.人体 T 细胞对植物提取物和商业护肤品中 CD1a 和接触性皮炎过敏原的反应。
Sci Immunol. 2020 Jan 3;5(43). doi: 10.1126/sciimmunol.aax5430.
4
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.急性非感染性皮肤炎症中人类 BDCA-2+ DC 的再评估。
J Exp Med. 2020 Mar 2;217(3). doi: 10.1084/jem.20190811.
5
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.鞘磷脂调控 CD1d 限制性抗原呈递和炎症反应
Nat Immunol. 2019 Dec;20(12):1644-1655. doi: 10.1038/s41590-019-0504-0. Epub 2019 Oct 21.
6
T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.针对 CD1c 自身而不是携带的自身脂质的 T 细胞自身反应性。
Nat Immunol. 2018 Apr;19(4):397-406. doi: 10.1038/s41590-018-0065-7. Epub 2018 Mar 12.
7
CD1a presentation of endogenous antigens by group 2 innate lymphoid cells.2 型固有淋巴细胞对内源性抗原的 CD1a 呈递。
Sci Immunol. 2017 Dec 22;2(18). doi: 10.1126/sciimmunol.aan5918.
8
Impaired Langerhans cell migration in psoriasis is due to an altered keratinocyte phenotype induced by interleukin-17.银屑病中朗格汉斯细胞迁移受损是由于白细胞介素-17诱导的角质形成细胞表型改变所致。
Br J Dermatol. 2018 Jun;178(6):1364-1372. doi: 10.1111/bjd.16172. Epub 2018 Mar 31.
9
An analysis of IL-36 signature genes and individuals with knockout mutations validates IL-36 as a psoriasis therapeutic target.IL-36 特征基因分析和 IL-36 基因敲除突变个体验证了 IL-36 是治疗银屑病的一个靶点。
Sci Transl Med. 2017 Oct 11;9(411). doi: 10.1126/scitranslmed.aan2514.
10
Contact sensitizers trigger human CD1-autoreactive T-cell responses.接触性致敏原可引发人类CD1自身反应性T细胞应答。
Eur J Immunol. 2017 Jul;47(7):1171-1180. doi: 10.1002/eji.201746939. Epub 2017 May 23.
Zotero 插件