Experimental and Clinical Research Center (ECRC), a Cooperation between Charité-Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany.
Berlin Institute of Health, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Nutrients. 2021 Dec 29;14(1):148. doi: 10.3390/nu14010148.
Each year in March, adherents of the Bahá'í faith abstain from eating and drinking from sunrise to sunset for 19 days. Thus, Bahá'í fasting (BF) can be considered as a form of daytime dry fasting. We investigated whether BF decreased energy expenditure after a meal and whether it improved anthropometric measures and systemic and tissue-level metabolic parameters. This was a self-controlled cohort study with 11 healthy men. We measured anthropometric parameters, metabolic markers in venous blood and pre- and postprandial energy metabolism at systemic (indirect calorimetry) and tissue (adipose tissue and skeletal muscle microdialysis) level, both before and during BF. During BF, we found reduced body weight, body mass index, body fat and blood glucose. Postprandial increase in energy expenditure was lower and diet-induced thermogenesis tended to be lower as well. In adipose tissue, perfusion, glucose supply and lipolysis were increased. In skeletal muscle, tissue perfusion did not change. Glucose supply and lipolysis were decreased. Glucose oxidation was increased, indicating improved insulin sensitivity. BF may be a promising approach to losing weight and improving metabolism and health. However, outside the context of religiously motivated fasting, skipping a meal in the evening (dinner cancelling) might be recommended, as metabolism appeared to be reduced in the evening.
每年三月，巴哈伊教信徒会进行为期 19 天的斋戒，从日出到日落期间禁食禁水。因此，巴哈伊教斋戒（BF）可以被视为一种白天的干式禁食。我们研究了 BF 是否会降低餐后能量消耗，以及它是否能改善人体测量学指标和全身及组织水平的代谢参数。这是一项自我对照的队列研究，共有 11 名健康男性参与。我们在 BF 前后测量了人体测量学参数、静脉血中的代谢标志物以及全身（间接测热法）和组织（脂肪组织和骨骼肌微透析）水平的餐前和餐后能量代谢。在 BF 期间，我们发现体重、体重指数、体脂肪和血糖降低。餐后能量消耗增加减少，饮食诱导的产热也倾向于减少。在脂肪组织中，灌注、葡萄糖供应和脂肪分解增加。在骨骼肌中，组织灌注没有变化。葡萄糖供应和脂肪分解减少。葡萄糖氧化增加，表明胰岛素敏感性提高。BF 可能是一种有前途的减肥和改善代谢和健康的方法。然而，在宗教禁食的背景之外，晚上不吃饭（取消晚餐）可能是被推荐的，因为晚上的代谢似乎会降低。
