Gill Shubhroz, Panda Satchidananda
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Cell Metab. 2015 Nov 3;22(5):789-98. doi: 10.1016/j.cmet.2015.09.005. Epub 2015 Sep 24.
A diurnal rhythm of eating-fasting promotes health, but the eating pattern of humans is rarely assessed. Using a mobile app, we monitored ingestion events in healthy adults with no shift-work for several days. Most subjects ate frequently and erratically throughout wakeful hours, and overnight fasting duration paralleled time in bed. There was a bias toward eating late, with an estimated <25% of calories being consumed before noon and >35% after 6 p.m. "Metabolic jetlag" resulting from weekday/weekend variation in eating pattern akin to travel across time zones was prevalent. The daily intake duration (95% interval) exceeded 14.75 hr for half of the cohort. When overweight individuals with >14 hr eating duration ate for only 10-11 hr daily for 16 weeks assisted by a data visualization (raster plot of dietary intake pattern, "feedogram") that we developed, they reduced body weight, reported being energetic, and improved sleep. Benefits persisted for a year.
进食-禁食的昼夜节律有益健康，但人类的饮食模式却很少得到评估。我们使用一款移动应用程序，对无轮班工作的健康成年人的进食情况进行了数天监测。大多数受试者在清醒时间内频繁且不规律地进食，夜间禁食时长与卧床时间相近。存在晚餐进食偏多的倾向，估计中午之前摄入的热量不到25%，下午6点之后摄入的热量超过35%。工作日/周末饮食模式的变化类似于跨时区旅行所导致的“代谢时差”现象很普遍。一半队列人群的每日进食时长（95%区间）超过14.75小时。当我们开发的数据可视化工具（饮食摄入模式的光栅图，即“饮食记录图”）辅助下，进食时长超过14小时的超重个体每天仅进食10-11小时，持续16周后，他们体重减轻，称精力充沛，睡眠也得到改善。这些益处持续了一年。
