CRBS, UR3072: Mitochondria, Oxidative Stress and Muscular Protection, University of Strasbourg, 1 rue Eugène Boeckel, 67000 Strasbourg, France.
Nutrients. 2021 Apr 22;13(5):1405. doi: 10.3390/nu13051405.
The importance of metabolic health is a major societal concern due to the increasing prevalence of metabolic diseases such as obesity, diabetes, and various cardiovascular diseases. The circadian clock is clearly implicated in the development of these metabolic diseases. Indeed, it regulates physiological processes by hormone modulation, thus helping the body to perform them at the ideal time of day. Since the industrial revolution, the actions and rhythms of everyday life have been modified and are characterized by changes in sleep pattern, work schedules, and eating habits. These modifications have in turn lead to night shift, social jetlag, late-night eating, and meal skipping, a group of customs that causes circadian rhythm disruption and leads to an increase in metabolic risks. Intermittent fasting, especially the time-restricted eating, proposes a solution: restraining the feeding window from 6 to 10 h per day to match it with the circadian clock. This approach seems to improve metabolic health markers and could be a therapeutic solution to fight against metabolic diseases. This review summarizes the importance of matching life habits with circadian rhythms for metabolic health and assesses the advantages and limits of the application of time-restricted fasting with the objective of treating and preventing metabolic diseases.
代谢健康的重要性是一个主要的社会关注点，因为代谢疾病的患病率不断上升，如肥胖、糖尿病和各种心血管疾病。昼夜节律显然与这些代谢疾病的发展有关。事实上，它通过激素调节来调节生理过程，从而帮助身体在一天中的理想时间进行这些生理过程。自工业革命以来，日常生活的活动和节奏发生了变化，其特征是睡眠模式、工作时间表和饮食习惯的改变。这些变化反过来又导致了夜班、社交时差、深夜进食和不规律用餐，这一系列的习惯导致了昼夜节律紊乱，并增加了代谢风险。间歇性禁食，特别是限时进食，提供了一种解决方案：将进食窗口限制在每天 6 到 10 小时，以使其与生物钟相匹配。这种方法似乎可以改善代谢健康标志物，可能是对抗代谢疾病的一种治疗方法。这篇综述总结了使生活习惯与昼夜节律相匹配对代谢健康的重要性，并评估了限时进食的应用的优点和局限性，目的是治疗和预防代谢疾病。
