Department of Pharmacy, University of Pisa, 56126 Pisa, Italy.
Molecules. 2021 Dec 21;27(1):2. doi: 10.3390/molecules27010002.
Deemed as poorly represented in nature, aurones have been often overlooked by researchers compared to other members of the flavonoid superfamily. However, over the past two decades, they have been reassessed by the scientific community, who are increasingly appreciating their ability to modulate several biological pathways. This review summarizes the recent literature on this class of compounds, which has been analyzed from both a chemical and a functional point of view. Original articles, reviews and editorials featured in Pubmed and Scifinder over the last twenty years have been taken into account to provide the readers with a view of the chemical strategies to obtain them, their functional properties, and their potential of technological use. The resulting comprehensive picture aims at raising the awareness of these natural derivatives as effective drug candidates, fostering the development of novel synthetic analogues.
被认为在自然界中代表性不足，与类黄酮超家族的其他成员相比，查耳酮经常被研究人员忽视。然而，在过去的二十年中，它们被科学界重新评估，人们越来越欣赏它们调节几种生物途径的能力。本综述总结了近年来关于这一类化合物的文献，从化学和功能两个方面对其进行了分析。考虑到过去 20 年来在 Pubmed 和 Scifinder 上发表的原始文章、综述和社论，为读者提供了获得它们的化学策略、功能特性及其技术应用潜力的视角。由此产生的综合图景旨在提高人们对这些天然衍生物作为有效药物候选物的认识，促进新型合成类似物的开发。
