College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia.
College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia.
Eur J Med Chem. 2019 Mar 15;166:417-431. doi: 10.1016/j.ejmech.2019.01.078. Epub 2019 Feb 1.
Aurones are very simple, promising anticancer lead molecules containing three rings (A, B and C). A very slight structural variation in the aurones elicits diverse affinity and specificity towards different molecular targets. The present review discusses the design, discovery and development of natural and synthetic aurones as small molecule anticancer agents. Detailed structure-activity relationship and intermolecular interactions at different targets are also discussed. Due to their rare occurrence in nature and minimal mention in literature, the anticancer potential of aurones is rather recent but in constant progress.
奥罗宁是非常简单的、有前途的抗癌先导分子，含有三个环（A、B 和 C）。奥罗宁的结构稍有变化，就会对不同的分子靶标产生不同的亲和力和特异性。本综述讨论了天然和合成奥罗宁作为小分子抗癌剂的设计、发现和开发。还讨论了不同靶标处的详细结构-活性关系和分子间相互作用。由于奥罗宁在自然界中罕见且文献中鲜有提及，因此其抗癌潜力是最近才发现的，但一直在不断发展。
