评估一种以香豆素为配体的铜（I）同型配合物对传染性胰腺坏死病毒（IPNV）的抗病毒活性。
Evaluation of the Antiviral Activity against Infectious Pancreatic Necrosis Virus (IPNV) of a Copper (I) Homoleptic Complex with a Coumarin as Ligand.
机构信息
Laboratory of Natural Product Chemistry, Center of Aquatic Biotechnology, Department of Environmental Sciences, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago 3363, Chile.
Laboratory of Computational Simulations and Rational Drug Design, Department of Environmental Sciences, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago 3363, Chile.
出版信息
Molecules. 2021 Dec 22;27(1):32. doi: 10.3390/molecules27010032.
The aquatic infectious pancreatic necrosis virus (IPNV) causes a severe disease in farmed salmonid fish that generates great economic losses in the aquaculture industry. In the search for new tools to control the disease, in this paper we show the results obtained from the evaluation of the antiviral effect of Cu(NN) Cu(I) complex, synthesized in our laboratory, where the NN ligand is a synthetic derivate of the natural compound coumarin. This complex demonstrated antiviral activity against IPNV at 5.0 and 15.0 µg/mL causing a decrease viral load 99.0% and 99.5%, respectively. The Molecular Docking studies carried out showed that the copper complex would interact with the VP2 protein, specifically in the S domain, altering the process of entry of the virus into the host cell.
水产养殖传染性胰腺坏死病毒 (IPNV) 可引起养殖鲑鱼的严重疾病，给水产养殖业造成巨大的经济损失。为了寻找控制疾病的新方法，本文报告了我们对实验室合成的Cu(NN) Cu(I) 配合物的抗病毒效果评估结果，其中 NN 配体是天然香豆素化合物的合成衍生物。该配合物在 5.0 和 15.0 µg/mL 浓度下对 IPNV 表现出抗病毒活性，分别使病毒载量降低 99.0%和 99.5%。进行的分子对接研究表明，铜配合物将与 VP2 蛋白相互作用，特别是在 S 结构域，从而改变病毒进入宿主细胞的过程。
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