Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Molecules. 2021 Dec 28;27(1):152. doi: 10.3390/molecules27010152.
Macrophages have diverse functions in the pathogenesis, resolution, and repair of inflammatory processes. Elegant studies have elucidated the metabolomic and transcriptomic profiles of activated macrophages. However, the versatility of macrophage responses in inflammation is likely due, at least in part, to their ability to rearrange their repertoire of bioactive lipids, including fatty acids and oxylipins. This review will describe the fatty acids and oxylipins generated by macrophages and their role in type 1 and type 2 immune responses. We will highlight lipidomic studies that have shaped the current understanding of the role of lipids in macrophage polarization.
巨噬细胞在炎症过程的发病机制、消退和修复中具有多种功能。精心设计的研究已经阐明了活化巨噬细胞的代谢组学和转录组学特征。然而，巨噬细胞在炎症中的反应的多样性可能至少部分归因于它们重新排列生物活性脂质（包括脂肪酸和氧化脂类）谱的能力。本综述将描述巨噬细胞产生的脂肪酸和氧化脂类及其在 1 型和 2 型免疫反应中的作用。我们将重点介绍脂质组学研究，这些研究改变了人们对脂质在巨噬细胞极化中的作用的认识。
