Kaada B
Laboratory of Clinical Neurophysiology, Rogaland Central Hospital, Stavanger, Norway.
Scand J Gastroenterol. 1987 Nov;22(9):1137-46. doi: 10.3109/00365528708991971.
Dysphagia has been successfully treated by low-frequency transcutaneous nerve stimulation (TNS) in two patients with achalasia and in six patients with systemic sclerosis. A 30- to 45-min stimulation session was followed by augmentation of peristalsis in the lower half of the esophagus and relaxation of the gastroesophageal sphincter, with relief of dysphagia. The sclerotic patients were also relieved of invaliding Raynaud's phenomenon. One 30-min daily stimulation session, and later one session every 2nd or 3rd day, was sufficient to prevent relapse. After months or years of TNS treatment the stimulation could in three patients be withdrawn with no recurrence. A stimulation session produced about 30% increase in plasma vasoactive intestinal polypeptides. Activation of this neuromodulator is considered to be the cause of the beneficial effects on dysphagia and Raynaud's phenomenon.
两名贲门失弛缓症患者和六名系统性硬化症患者通过低频经皮神经刺激（TNS）成功治疗吞咽困难。30至45分钟的刺激疗程后，食管下半段蠕动增强，胃食管括约肌松弛，吞咽困难缓解。硬化症患者的致残性雷诺现象也得到缓解。每天一次30分钟的刺激疗程，随后每2或3天一次，足以防止复发。经过数月或数年的TNS治疗，三名患者可以停止刺激且无复发。一次刺激疗程可使血浆血管活性肠多肽增加约30%。这种神经调节剂的激活被认为是对吞咽困难和雷诺现象产生有益作用的原因。
