Woo Yu-Ri, Wang Sehee, Sohn Kyung-Ah, Kim Hei-Sung
Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul 06591, Korea.
Department of Artificial Intelligence, College of Information Technology, Ajou University, Suwon 16499, Korea.
J Clin Med. 2021 Dec 24;11(1):95. doi: 10.3390/jcm11010095.
Prurigo nodularis (PN) is a chronic dermatosis typified by extraordinarily itchy nodules. However, little is known of the nature and extent of PN in Asian people. This study aimed to describe the epidemiology, comorbidities, and prescription pattern of PN in Koreans based on a large dermatology outpatient cohort. Patients with PN were identified from the Catholic Medical Center (CMC) clinical data warehouse. Anonymized data on age, sex, diagnostic codes, prescriptions, visitation dates, and other relevant parameters were collected. Pearson correlation analysis was used to calculate the correlation between PN prevalence and patient age. Conditional logistic regression modeling was adopted to measure the comorbidity risk of PN. A total of 3591 patients with PN were identified at the Catholic Medical Center Health System dermatology outpatient clinic in the period 2007-2020. A comparison of the study patients with age- and sex-matched controls (dermatology outpatients without PN) indicated that PN was associated with various comorbidities including chronic kidney disease (adjusted odds ratio (aOR), 1.48; 95% confidence interval (CI), 1.29-1.70), dyslipidemia (aOR, 1.88; 95% CI, 1.56-2.27), type 2 diabetes mellitus (aOR, 1.37; 95% CI, 1.22-1.54), arterial hypertension (aOR, 1.50; 95% CI, 1.30-1.73), autoimmune thyroiditis (aOR, 2.43; 95% CI, 1.42-4.16), non-Hodgkin's lymphoma (aOR, 1.95; 95% CI, 1.23-3.07), and atopic dermatitis (aOR, 2.16, 95% CI, 1.91-2.45). Regarding prescription patterns, topical steroids were most favored, followed by topical calcineurin inhibitors; oral antihistamines were the most preferred systemic agent for PN. PN is a relatively rare but significant disease among Korean dermatology outpatients with a high comorbidity burden compared to dermatology outpatients without PN. There is great need for breakthroughs in PN treatment.
结节性痒疹（PN）是一种以极度瘙痒的结节为特征的慢性皮肤病。然而，对于亚洲人群中PN的性质和范围知之甚少。本研究旨在基于一个大型皮肤科门诊队列描述韩国人PN的流行病学、合并症及处方模式。从天主教医疗中心（CMC）临床数据仓库中识别出PN患者。收集了年龄、性别、诊断编码、处方、就诊日期及其他相关参数的匿名数据。采用Pearson相关分析计算PN患病率与患者年龄之间的相关性。采用条件逻辑回归模型评估PN的合并症风险。在2007年至2020年期间，天主教医疗中心卫生系统皮肤科门诊共识别出3591例PN患者。将研究患者与年龄和性别匹配的对照组（无PN的皮肤科门诊患者）进行比较，结果表明PN与多种合并症相关，包括慢性肾脏病（调整优势比（aOR），1.48；95%置信区间（CI），1.29 - 1.70）、血脂异常（aOR，1.88；95% CI，1.56 - 2.2）、2型糖尿病（aOR，1.37；95% CI，1.22 - 1.54）、动脉高血压（aOR，1.50；95% CI，1.30 - 1.73）、自身免疫性甲状腺炎（aOR，2.43；95% CI，1.42 - 4.16）、非霍奇金淋巴瘤（aOR，1.95；95% CI，1.23 - 3.07）和特应性皮炎（aOR，2.16，95% CI，1.91 - 2.45）。关于处方模式，局部用类固醇最受青睐，其次是局部用钙调神经磷酸酶抑制剂；口服抗组胺药是PN最常用的全身性药物。与无PN的皮肤科门诊患者相比，PN在韩国皮肤科门诊患者中是一种相对罕见但重要的疾病，合并症负担较高。PN治疗急需取得突破。
