Dermatology Hospital of Southern Medical University, Guangzhou, China.
Dermatology Services, Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California, USA.
J Diabetes. 2022 Sep;14(9):586-595. doi: 10.1111/1753-0407.13303. Epub 2022 Aug 31.
Epidermal function is regulated by numerous exogenous and endogenous factors, including age, psychological stress, certain skin disorders, ultraviolet irradiation and pollution, and epidermal function itself can regulate cutaneous and extracutaneous functions. The biophysical properties of the stratum corneum reflect the status of both epidermal function and systemic conditions. Type 2 diabetes in both murine models and humans displays alterations in epidermal functions, including reduced levels of stratum corneum hydration and increased epidermal permeability as well as delayed permeability barrier recovery, which can all provoke and exacerbate cutaneous inflammation. Because inflammation plays a pathogenic role in type 2 diabetes, a therapy that improves epidermal functions could be an alternative approach to mitigating type 2 diabetes and its associated cutaneous disorders.
表皮功能受许多外源性和内源性因素的调节，包括年龄、心理压力、某些皮肤疾病、紫外线照射和污染，而表皮功能本身可以调节皮肤和皮肤外的功能。角质层的生物物理特性反映了表皮功能和全身状况的状态。在小鼠模型和人类中，2 型糖尿病都表现出表皮功能的改变，包括角质层水分含量降低、表皮通透性增加以及渗透性屏障恢复延迟，这些都会引发和加剧皮肤炎症。由于炎症在 2 型糖尿病中起致病作用，改善表皮功能的治疗方法可能是减轻 2 型糖尿病及其相关皮肤疾病的一种替代方法。
