Sugimoto Masahiko, Sampa Kohei, Tsukitome Hideyuki, Kato Kumiko, Matsubara Hisashi, Asami Shin, Sekimoto Kaori, Kitano Shigehiko, Yoshida Shigeo, Takamura Yoshihiro, Hirano Takao, Murata Toshinori, Shimizu Miho, Kinoshita Takamasa, Kusuhara Sentaro, Sawada Osamu, Ohji Masahito, Yoshikawa Rina, Kimura Kazuhiro, Ishikawa Hiroto, Gomi Fumi, Terasaki Hiroto, Kondo Mineo, Ikeda Tomoaki
Department of Ophthalmology, Graduate School of Medicine, Mie University, Tsu 514-8507, Japan.
Graduate School of Medicine, Faculty of Medicine, Mie University, Tsu 514-8507, Japan.
J Clin Med. 2021 Dec 29;11(1):165. doi: 10.3390/jcm11010165.
The aim of this study was to determine the prevalence and progression of diabetic retinopathy (DR) with hyperglycemic disorders during pregnancy (HDPs) in Japan between 2013 and 2018 using two cohorts. The patients with HDPs were classified as those with pre-existing DM (pexD), gestational DM (GDM), and overt DM (ODM). Cohort 1 was obtained from the health claims database whose diseases were classified by the International Classification of Diseases-10. Cohort 2 was derived from a retrospective, multicenter analysis of the medical records of 225 patients from 10 ophthalmological institutions. In Cohort 1, there were 5268 patients with an HDP prevalence of 8.4%. Among them, 73 of 1139 patients had pexD (6.4%) and 61 of 4129 patients with GDM (1.5%) had DR; the overall prevalence of DR was 2.5%. In Cohort 2, 36 of 225 patients (16.0%) had DR, and 149 patients were followed at the early and late stages of pregnancy. Moreover, 10 of the 102 patients with pexD (9.8%) and two of five patients with ODM (40.0%) had a progression of DR. In conclusion, the prevalence and progression of DR in patients with pexD is lower than previously reported. More attention should be given to pexD and ODM.
本研究旨在利用两个队列确定2013年至2018年期间日本妊娠期间高血糖疾病（HDPs）患者糖尿病视网膜病变（DR）的患病率和进展情况。患有HDPs的患者被分为患有既往糖尿病（pexD）、妊娠期糖尿病（GDM）和显性糖尿病（ODM）的患者。队列1来自健康保险理赔数据库，其疾病按照国际疾病分类第10版进行分类。队列2来自对10家眼科机构225例患者病历的回顾性多中心分析。在队列1中，有5268例HDPs患者，患病率为8.4%。其中，1139例pexD患者中有73例（6.4%）患有DR，4129例GDM患者中有61例（1.5%）患有DR；DR的总体患病率为2.5%。在队列2中，225例患者中有36例（16.0%）患有DR，149例患者在妊娠早期和晚期接受了随访。此外，102例pexD患者中有10例（9.8%）和5例ODM患者中有2例（40.0%）出现了DR进展。总之，pexD患者DR的患病率和进展低于先前报道。应更多关注pexD和ODM。
