Dawidowski Bartosz, Grelecki Grzegorz, Biłgorajski Adam, Podwalski Piotr, Misiak Błażej, Samochowiec Jerzy
Department of Psychiatry, Pomeranian Medical University, 71-460 Szczecin, Poland.
Department of Psychiatry, Division of Consultation Psychiatry and Neuroscience, Wroclaw Medical University, 50-367 Wroclaw, Poland.
J Clin Med. 2021 Dec 31;11(1):232. doi: 10.3390/jcm11010232.
Studies have shown that there are deviations in the results of peripheral blood counts, which lead to increased values of the neutrophils-to-lymphocytes ratio (NLR) in schizophrenia. Antipsychotic drugs have proven to lower the levels of pro-inflammatory cytokines and a growing number of studies indicate a similar effect on NLR values.
We identified inpatients with schizophrenia and collected data of NLR at the beginning (NLR) and end (NLR) of hospitalization, the status of antipsychotic medication on admission and potential confounding factors. In the statistical analysis, we applied a linear mixed model.
After the inclusion and exclusion process the records of 40 patients (n = 40) and 71 hospitalizations (n = 71) were analyzed. We found that in the group of antipsychotics-naive patients, the NLR were significantly higher than the NLR values. Such a difference did not occur in the case of non-antipsychotics-naïve patients. Age and the diagnosis of hypothyroidism influenced the value of change in NLR from the beginning to the end of hospitalization in a given patient (ΔNLR).
The study confirmed the lowering effect of antipsychotics on NLR values in psychosis. The NLR may potentially be a tool for assessing response to treatment with antipsychotics.
研究表明，外周血细胞计数结果存在偏差，这导致精神分裂症患者的中性粒细胞与淋巴细胞比值（NLR）升高。抗精神病药物已被证明可降低促炎细胞因子水平，并且越来越多的研究表明其对NLR值有类似影响。
我们确定了精神分裂症住院患者，并收集了住院开始时（NLR₁）和结束时（NLR₂）的NLR数据、入院时的抗精神病药物使用情况以及潜在的混杂因素。在统计分析中，我们应用了线性混合模型。
经过纳入和排除过程，分析了40例患者（n = 40）的71次住院记录（n = 71）。我们发现，在未使用过抗精神病药物的患者组中，NLR₁显著高于NLR₂值。在使用过抗精神病药物的患者中未出现这种差异。年龄和甲状腺功能减退的诊断影响了特定患者从住院开始到结束时NLR的变化值（ΔNLR）。
该研究证实了抗精神病药物对精神病患者NLR值的降低作用。NLR可能是评估抗精神病药物治疗反应的一种工具。
