Wang Xuan, Chen Xiaofang, Guan Xiaoni, Li Zezhi
Hebei Province Veterans Hospital, Baoding, China.
Peking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Beijing, China.
Schizophrenia (Heidelb). 2024 Feb 3;10(1):13. doi: 10.1038/s41537-024-00437-5.
Innate immunity has been shown to be associated with schizophrenia (Sch). This study explored the relationship between symptoms and neutrophil-to-lymphocyte ratio (NLR) (a marker of innate immunity) in patients with Sch. Ninety-seven first-episode medication-naïve (FEMN) patients with Sch and 65 healthy controls were recruited in this study. We measured the complete blood count and assessed the clinical symptoms using the PANSS scales. We found higher NEU counts and NLR in patients with Sch compared with control subjects. Male patients showed a higher NEU count than female patients. In addition, FEMN patients with higher NLR and NEU values showed higher PANSS-p, PANSS-g, and PANSS-total scores (all p < 0.05). Regression analysis revealed that NLR was a predictor for PANSS total scores in patients with Sch. Higher NLR value was observed in patients with Sch and the significant associations between NLR and psychotic symptoms indicate that an imbalance in inflammation and innate immune system may be involved in the pathophysiology of Sch.
先天免疫已被证明与精神分裂症（Sch）有关。本研究探讨了精神分裂症患者症状与中性粒细胞与淋巴细胞比值（NLR，一种先天免疫标志物）之间的关系。本研究招募了97例首发未用药的精神分裂症患者（FEMN）和65名健康对照者。我们测量了全血细胞计数，并使用阳性和阴性症状量表（PANSS）评估临床症状。我们发现，与对照受试者相比，精神分裂症患者的中性粒细胞计数（NEU）和NLR更高。男性患者的NEU计数高于女性患者。此外，NLR和NEU值较高的FEMN患者的PANSS阳性量表（PANSS-p）、PANSS阴性量表（PANSS-g）和PANSS总分更高（所有p<0.05）。回归分析显示，NLR是精神分裂症患者PANSS总分的一个预测指标。在精神分裂症患者中观察到较高的NLR值，并且NLR与精神病性症状之间的显著关联表明，炎症和先天免疫系统的失衡可能参与了精神分裂症的病理生理学过程。
