Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.
Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, China.
Front Immunol. 2024 Jan 30;15:1337103. doi: 10.3389/fimmu.2024.1337103. eCollection 2024.
There is a growing amount of evidence suggesting that immunity and inflammation play an important role in the pathophysiology of schizophrenia. In this study, we aimed to examine the relationship between hematological and inflammatory markers with symptom severity in Han Chinese patients with drug-free schizophrenia.
This retrospective study was conducted at Chaohu Hospital of Anhui Medical University and data were extracted from the electronic medical record system over a 5-year period (May 2017 to April 2022), including participants' general and clinical information as well as Brief Psychiatric Rating Scale (BPRS) scores and hematological parameters.
A total of 2,899 patients with schizophrenia were identified through the initial search. After screening, 91 patients and 141 healthy controls (HCs) were included. The patients had a higher value of neutrophils/lymphocytes ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) than HCs (all < 0.001). MLR was positively correlated with BPRS total score ( = 0.337, = 0.001) and resistance subscale score ( = 0.350, = 0.001). Binary logistic regression analyses revealed that severely ill was significantly associated with being male and a higher value of MLR (Natural Logaruthm, Ln) (all 0.05), and the receiver operating characteristic (ROC) analysis showed good performance of a regression model with an area under the curve (AUC) value of 0.787.
Patients with drug-free schizophrenia have an unbalanced distribution of peripheral blood granulocytes, and elevated NLR, MLR and PLR. Patients with higher value of MLR tend to have more psychotic symptoms, especially those symptoms of hostility, uncooperativeness, and suspiciousness. Our study gives a preliminary indication that MLR is a potential predictor of disease severity in patients with drug-free schizophrenia.
越来越多的证据表明，免疫和炎症在精神分裂症的病理生理学中起着重要作用。在这项研究中，我们旨在研究汉族未经药物治疗的精神分裂症患者的血液学和炎症标志物与症状严重程度之间的关系。
本回顾性研究在安徽医科大学巢湖医院进行，数据来自电子病历系统，时间跨度为 5 年（2017 年 5 月至 2022 年 4 月），包括参与者的一般和临床信息，以及简明精神病评定量表（BPRS）评分和血液学参数。
通过初步搜索，共确定了 2899 名精神分裂症患者。经过筛选，纳入了 91 名患者和 141 名健康对照者（HCs）。患者的中性粒细胞/淋巴细胞比值（NLR）、单核细胞/淋巴细胞比值（MLR）和血小板/淋巴细胞比值（PLR）均高于 HCs（均<0.001）。MLR 与 BPRS 总分（=0.337，=0.001）和抵抗分量表评分（=0.350，=0.001）呈正相关。二元逻辑回归分析显示，严重程度与男性和较高的 MLR 值显著相关（自然对数，Ln）（均<0.05），ROC 分析显示，回归模型的曲线下面积（AUC）值为 0.787，表现出良好的性能。
未经药物治疗的精神分裂症患者外周血粒细胞分布不平衡，NLR、MLR 和 PLR 升高。MLR 值较高的患者往往有更多的精神病症状，特别是敌意、不合作和怀疑症状。我们的研究初步表明，MLR 是未经药物治疗的精神分裂症患者疾病严重程度的一个潜在预测指标。
