Chaiwong Nareekan, Phimolsiripol Yuthana, Leelapornpisid Pimporn, Ruksiriwanich Warintorn, Jantanasakulwong Kittisak, Rachtanapun Pornchai, Seesuriyachan Phisit, Sommano Sarana Rose, Leksawasdi Noppol, Simirgiotis Mario J, Barba Francisco J, Punyodom Winita
Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.
Cluster of Agro Bio-Circular-Green Industry, Chiang Mai University, Chiang Mai 50100, Thailand.
Polymers (Basel). 2022 Jan 3;14(1):178. doi: 10.3390/polym14010178.
Carboxymethyl chitosan (CMCH) from native chitosan of high molecular weight (H, 310-375 kDa) was synthesized for improving water solubility. The water solubility of high-molecular-weight carboxymethyl chitosan (H-CMCH) was higher than that of native chitosan by 89%. The application of H-CMCH as enhancing the moisturizer in mangosteen extract deodorant cream was evaluated. Different concentrations of H-CMCH (0.5-2.5%) were investigated in physicochemical characteristics of creams, including appearance, phase separation, pH, and viscosity, by an accelerated stability test. The different degrees of skin moisturizing (DM) on pig skin after applying H-CMCH solution, compared with untreated skin, water, and propylene glycol for 15 and 30 min using a Corneometer, were investigated. The results showed that the 0.5% H-CMCH provided the best DM after applying the solution on pig skin for 30 min. Trans-2-nonenal, as an unsatisfied odor component, was also evaluated against components of the mangosteen extract deodorant cream, which were compared to the standard, epigallocatechin gallate (EGCG). In addition, DPPH and ABTS radical scavenging activity, ferric reducing antioxidant power (FRAP), and antibacterial activities were examined for the mangosteen extract deodorant cream using 0.5% H-CMCH. Results indicated that the mangosteen extract synergized with H-CMCH, which had a good potential as an effective skin moisturizing agent enhancer, deodorizing activity on trans-2-nonenal odor, antioxidant properties, and antibacterial properties.
为提高水溶性，合成了由高分子量（H，310 - 375 kDa）天然壳聚糖制备的羧甲基壳聚糖（CMCH）。高分子量羧甲基壳聚糖（H - CMCH）的水溶性比天然壳聚糖高89%。评估了H - CMCH作为山竹提取物除臭霜中保湿增强剂的应用。通过加速稳定性试验，研究了不同浓度（0.5 - 2.5%）的H - CMCH对乳膏理化特性的影响，包括外观、相分离、pH值和粘度。使用角质层水合测定仪，研究了在猪皮肤上涂抹H - CMCH溶液、未处理皮肤、水和丙二醇15分钟和30分钟后不同程度的皮肤保湿情况。结果表明，在猪皮肤上涂抹溶液30分钟后，0.5%的H - CMCH提供了最佳的皮肤保湿效果。还针对山竹提取物除臭霜的成分评估了反 - 2 - 壬烯醛，将其与标准品表没食子儿茶素没食子酸酯（EGCG）进行比较。此外，对使用0.5% H - CMCH的山竹提取物除臭霜进行了DPPH和ABTS自由基清除活性、铁还原抗氧化能力（FRAP）以及抗菌活性检测。结果表明，山竹提取物与H - CMCH协同作用，H - CMCH作为一种有效的皮肤保湿剂增强剂、对反 - 2 - 壬烯醛气味的除臭活性、抗氧化性能和抗菌性能具有良好的潜力。
