One of the most prolific plants utilized in various applications is mangosteen ( L.). Rich in potent bioactive compounds, such as xanthones, mangosteen is known to possess pharmacologically important anti-inflammatory and anti-tumor properties. However, most previous reviews have only discussed the application of mangosteen in medicinal areas, yet more recent studies have diverged and valorized its usage in other scientific fields. In this review, the utilization of this exotic fruit in postharvest biology (phytohormone roles, metabolite profiling, bioactive compounds, isolation method optimization, chemical contaminant identification, and management of pests and fruit disorders), food science (food products, animal feed supplementation, and food shelf-life determination), and engineering fields (fabric and solar cell dyes, carbon dots, activated carbon, and biomedical advanced materials) is presented in detail. Research papers published from 2016 onward were selected and reviewed to show the recent research trends in these areas. In conclusion, mangosteen has been utilized for various purposes, ranging from usage in industrially important products to applications in advanced technologies and biomedical innovation.