Department of Obstetrics and Gynecology, Taipei City Hospital, Women and Children Campus, 155 Linong Street, Sec. 2, Beitou, Taipei, 112, Taiwan.
Departmen of Biomedical Engineering, National Yang Ming Chiao Tung University, 155 Linong Street, Sec. 2, Beitou, Taipei, 112, Taiwan.
BMC Pregnancy Childbirth. 2022 Jan 9;22(1):23. doi: 10.1186/s12884-021-04360-w.
The purpose of this study is to evaluate the impact of prenatal screening tests on prenatal diagnosis in Taiwan's 14 years from 2006 to 2019.
The prenatal screening methods evolved from the second-trimester serum screening to combined first-trimester screening (cFTS) and then followed by the non-invasive cell-free DNA prenatal test (NIPT). The data used by the Department of Statistics, the Ministry of Health and Welfare and Department of Household Registration, Ministry of the Interior public website.
This regional registry-based cohort retrospective study examined a total of 2,775,792 births from January 2006 to December 2019. The proportion of advanced maternal age (AMA) pregnancies increased from 11.63% in 2006 to 30.94% in 2019. Overall, invasive diagnostic testing was used in 87.22% of AMA pregnancies. The prenatal detection rate of trisomy 21 and 18 increased from 74.1% and 83.3% in 2006 to 96.9% and 98.8% in 2019, respectively.
During the second-trimester and cFTS periods, the percentage of AMA pregnancies increased every year and the number of invasive procedures also accompany with increased percentage of AMA. However, during the period that NIPT were implemented, the percentage of invasive procedures decreased.
本研究旨在评估 2006 年至 2019 年台湾 14 年来产前筛查试验对产前诊断的影响。
产前筛查方法从孕中期血清筛查发展为联合孕早期筛查（cFTS），随后是无创性游离胎儿 DNA 产前检测（NIPT）。本研究使用了卫生福利部统计处、内政部户政司公共网站的数据。
本区域注册队列回顾性研究共纳入了 2775792 例 2006 年 1 月至 2019 年 12 月的分娩。高龄产妇（AMA）妊娠的比例从 2006 年的 11.63%增加到 2019 年的 30.94%。总体而言，AMA 妊娠中侵袭性诊断检测的使用率为 87.22%。21 三体和 18 三体的产前检出率从 2006 年的 74.1%和 83.3%分别增加到 2019 年的 96.9%和 98.8%。
在中孕期和 cFTS 期间，AMA 妊娠的比例每年都在增加，侵袭性操作的数量也伴随着 AMA 比例的增加而增加。然而，在 NIPT 实施期间，侵袭性操作的比例有所下降。
