School of Mental Health, Wenzhou Medical University, Wenzhou, 325035, China.
Department of Obstetrics, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
BMC Pregnancy Childbirth. 2022 Jan 10;22(1):24. doi: 10.1186/s12884-021-04316-0.
Current research on perinatal depression rarely pays attention to the continuity and volatility of depression symptoms over time, which is very important for the early prediction and prognostic evaluation of perinatal depression. This study investigated the trajectories of perinatal depression symptoms and aimed to explore the factors related to these trajectories.
The study recruited 550 women during late pregnancy (32 ± 4 weeks of gestation) and followed them up 1 and 6 weeks postpartum. Depressive symptoms were measured using the Edinburgh Postnatal Depression Scale (EPDS). Latent growth mixture modelling (LGMM) was used to identify trajectories of depressive symptoms during pregnancy.
Two trajectories of perinatal depressive symptoms were identified: "decreasing" (n = 524, 95.3%) and "increasing" (n = 26, 4.7%). History of smoking, alcohol use and gestational hypertension increased the chance of belonging to the increasing trajectories, and a high level of social support was a protective factor for maintaining a decreasing trajectory.
This study identified two trajectories of perinatal depression and the factors associated with each trajectory. Paying attention to these factors and providing necessary psychological support services during pregnancy would effectively reduce the incidence of perinatal depression and improve patient prognosis.
目前针对围产期抑郁的研究很少关注抑郁症状随时间的连续性和波动性，这对于围产期抑郁的早期预测和预后评估非常重要。本研究探讨了围产期抑郁症状的轨迹，并旨在探讨与这些轨迹相关的因素。
该研究在妊娠晚期（32±4 周妊娠）招募了 550 名女性，并在产后 1 周和 6 周时对其进行了随访。使用爱丁堡产后抑郁量表（EPDS）测量抑郁症状。采用潜在增长混合模型（LGMM）来识别妊娠期间抑郁症状的轨迹。
确定了两种围产期抑郁症状轨迹：“下降”（n=524，95.3%）和“上升”（n=26，4.7%）。吸烟、饮酒和妊娠期高血压的病史增加了属于上升轨迹的机会，而高水平的社会支持是维持下降轨迹的保护因素。
本研究确定了两种围产期抑郁轨迹及其与每个轨迹相关的因素。在怀孕期间关注这些因素并提供必要的心理支持服务将有效降低围产期抑郁的发生率并改善患者预后。
