Craniofacial center, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.
Craniofacial center, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.
Int J Oral Maxillofac Surg. 2022 Jul;51(7):900-905. doi: 10.1016/j.ijom.2021.12.007. Epub 2022 Jan 7.
Botulinum toxin type A (BTA) injections into the subjacent orbicularis oris muscle have been shown to improve appearance and produce narrower cheiloplasty scars. This study was performed to determine the effect of BTA injected at different sites on the unilateral cleft lip scar and cleft side nostril width. A double-blind, randomized prospective trial was conducted involving 64 consecutive patients with unilateral cleft lip undergoing primary cheiloplasty between September 2016 and January 2019. The patients were randomized to receive BTA injections either into the subjacent orbicularis oris muscle (4 points group) or into the bilateral nasolabial fold region (6 points group) during cheiloplasty. The scars were assessed by photographic scar width measurements and Vancouver scar scale assessment tool. The cleft side nostril width was compared to the non-cleft side width. Fifty-six patients completed the trial, 24 in the 4 points group and 31 in the 6 points group. There was no significant difference in scar width or nostril width measurements between the groups at the end of follow-up. The Vancouver scar scale assessment was also similar between the groups. There was no significant difference in scar width or nostril width measurements after cleft lip repair between patients treated with botulinum toxin injections to the subjacent orbicularis oris muscle and patients treated with injections in the nasolabial region.
A型肉毒毒素（BTA）注射到下方的口轮匝肌已被证明可以改善外观并产生更窄的唇裂瘢痕。本研究旨在确定在不同部位注射 BTA 对单侧唇裂瘢痕和裂侧鼻孔宽度的影响。这是一项双盲、随机前瞻性试验，涉及 2016 年 9 月至 2019 年 1 月期间接受初次唇裂修复术的 64 例连续单侧唇裂患者。患者在唇裂修复术期间随机接受 BTA 注射到下方口轮匝肌（4 点组）或双侧鼻唇褶皱区域（6 点组）。通过照片瘢痕宽度测量和温哥华瘢痕量表评估工具评估瘢痕。比较裂侧鼻孔宽度与非裂侧宽度。56 例患者完成了试验，4 点组 24 例，6 点组 31 例。在随访结束时，两组之间的瘢痕宽度或鼻孔宽度测量值没有显著差异。两组之间温哥华瘢痕量表评估也相似。在唇裂修复后，接受 BTA 注射到下方口轮匝肌的患者与接受鼻唇区域注射的患者之间，瘢痕宽度或鼻孔宽度测量值没有显著差异。
