Leketas Marijus, Al Sayegh Bahaa, Latakas Dominykas, Stucinskaite-Maracinskiene Justina
Department of Maxillofacial Surgery, Faculty of Odontology, Medical Academy Lithuanian University of Health Sciences, KaunasLithuania.
J Oral Maxillofac Res. 2025 Jun 30;16(2):e1. doi: 10.5037/jomr.2025.16202. eCollection 2025 Apr-Jun.
Reduction of postoperative scarring after unilateral cleft lip cheiloplasty is a pertinent topic. Smaller scar formation results not only in a better lip function, but also - aesthetics. This systematic review aims to identify various supplementary treatment options which influence favourable scarring outcome after cheiloplasty.
The systematic review was conducted following PRISMA guidelines and Cochrane methodologies, using databases including PubMed, ScienceDirect, The Cochrane Library, and Google Scholar. Articles published between 2012 and 2024 evaluating supplementary measures for reducing scar tissue post-unilateral cleft lip cheiloplasty were included. Studies were assessed for bias using the Joanna Briggs Institute Critical Appraisal Checklist, and outcomes were measured using Vancouver Scar Scale, Visual Analog Scale, Hollander Wound Evaluation Score, and scar width metrics.
Nine studies were analysed, highlighting platelet-rich plasma and botulinum toxin A as effective in reducing scar width and improving aesthetics. Silicone-based products enhanced wound healing, while non-absorbable sutures and tissue adhesives showed superior outcomes compared to absorbable sutures. Overall, supplementary measures significantly improved postoperative scar appearance.
The use of platelet-rich plasma or botulinum toxin injections in musculus oribucalaris oris during the cheiloplasty significantly improves postoperative scar formation outcome. Wound edges approximation by non-absorbable sutures or tissue glue equally results in smaller scar formation and better aesthetic outcome. Suturing with absorbable sutures increases the incidence of complications and results in poor aesthetics. Postoperative wound care with products containing silicone significantly reduces scarring and aids in aesthetics.
减少单侧唇裂唇成形术后的瘢痕形成是一个相关话题。较小的瘢痕形成不仅能带来更好的唇部功能，还具有美学优势。本系统评价旨在确定影响唇成形术后瘢痕形成良好结果的各种辅助治疗选择。
本系统评价按照PRISMA指南和Cochrane方法进行，使用包括PubMed、ScienceDirect、Cochrane图书馆和谷歌学术在内的数据库。纳入2012年至2024年发表的评估单侧唇裂唇成形术后减少瘢痕组织辅助措施的文章。使用乔安娜·布里格斯研究所批判性评价清单评估研究的偏倚，并使用温哥华瘢痕量表、视觉模拟量表、霍兰德伤口评估评分和瘢痕宽度指标测量结果。
分析了9项研究，强调富血小板血浆和肉毒杆菌毒素A在减少瘢痕宽度和改善美学方面有效。硅基产品可促进伤口愈合，与可吸收缝线相比，不可吸收缝线和组织粘合剂显示出更好的效果。总体而言，辅助措施显著改善了术后瘢痕外观。
在唇成形术期间在口轮匝肌中使用富血小板血浆或肉毒杆菌毒素注射可显著改善术后瘢痕形成结果。用不可吸收缝线或组织胶水近似伤口边缘同样可减少瘢痕形成并获得更好的美学效果。使用可吸收缝线缝合会增加并发症发生率并导致美学效果不佳。使用含硅产品进行术后伤口护理可显著减少瘢痕形成并有助于改善美学效果。
