Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, National Center for Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Oral Diseases, Shanghai Research Institute of Stomatology, Shanghai, China.
BMC Oral Health. 2024 Nov 27;24(1):1443. doi: 10.1186/s12903-024-05205-6.
Current studies are controversial on the optimal treatment of postoperative scar treatment by cleft lip. Our objective is to elucidate the therapeutic effect of CO laser on postoperative cleft lip scar treatment.
A systematic review was performed and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We searched five electronic databases (EMBASE, PubMed, Web of Science, Cochrane Library and CNKI, from their inceptions until August 8, 2023) and independently assessed the methodological quality and bias risk of the included studies by two investigators using the Cochrane Handbook for Systematic Reviews. Quality assessment of the certainty of evidence was performed based on the Grading of Recommendations Assessment, Development, and Evaluation guidelines. Weighted mean difference of Vancouver Scar Scale were calculated to conduct meta-analysis by Stata statistical software version 14. We also estimated the pool sensitivity as well as testing the possibility of publication bias.
Five studies were included in this meta-analysis involving 255 subjects. Meta-analysis showed that compared with the control group, CO laser was more effective in treating post-cleft lip scars (WMD = 4.39, 95%CI = 0.54-8.23; Five studies with 255 participants; Low evidentiary certainty, I = 99.4%).
Patients treated with CO laser therapy for postoperative cleft lip scar treatment tend to have a significant therapeutic effect especially in the early stages.
identifier CRD42023397042 (18/02/2023) [ https://www.crd.york.ac.uk/prospero/ ].
目前关于唇裂术后瘢痕治疗的最佳治疗方法的研究存在争议。我们的目的是阐明 CO2 激光治疗对唇裂术后瘢痕的治疗效果。
按照系统评价和荟萃分析的首选报告项目进行系统评价，并进行报告。我们在五个电子数据库（EMBASE、PubMed、Web of Science、Cochrane Library 和中国知网）中进行了检索，从它们的建立到 2023 年 8 月 8 日，由两名研究者独立使用 Cochrane 系统评价手册评估纳入研究的方法学质量和偏倚风险。根据推荐评估、制定和评估指南对证据确定性进行质量评估。使用 Stata 统计软件版本 14 计算温哥华瘢痕量表的加权均数差进行荟萃分析。我们还估计了汇总敏感性，并检验了发表偏倚的可能性。
本荟萃分析共纳入 5 项研究，涉及 255 例患者。荟萃分析显示，与对照组相比，CO2 激光治疗唇裂术后瘢痕更有效（WMD=4.39，95%CI=0.54-8.23；五项研究，255 名参与者；低证据确定性，I=99.4%）。
接受 CO2 激光治疗的患者在治疗唇裂术后瘢痕方面往往具有显著的治疗效果，尤其是在早期阶段。
标识符 CRD42023397042（2023 年 2 月 18 日）[https://www.crd.york.ac.uk/prospero/]。
