Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China.
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Proc Natl Acad Sci U S A. 2022 Jan 18;119(3). doi: 10.1073/pnas.2106843119.
Preventing pathogenic viral and bacterial transmission in the human environment is critical, especially in potential outbreaks that may be caused by the release of ancient bacteria currently trapped in the permafrost. Existing commercial disinfectants present issues such as a high carbon footprint. This study proposes a sustainable alternative, a bioliquid derived from biomass prepared by hydrothermal liquefaction. Results indicate a high inactivation rate of pathogenic virus and bacteria by the as-prepared bioliquid, such as up to 99.99% for H1N1, H5N1, H7N9 influenza A virus, and var spores and 99.49% for Inactivation of and confirmed that low-molecular-weight and low-polarity compounds in bioliquid are potential antibacterial components. High temperatures promoted the production of antibacterial substances via depolymerization and dehydration reactions. Moreover, bioliquid was innoxious as confirmed by the rabbit skin test, and the cost per kilogram of the bioliquid was $0.04427, which is notably lower than that of commercial disinfectants. This study demonstrates the potential of biomass to support our biosafety with greater environmental sustainability.
防止人类环境中致病性病毒和细菌的传播至关重要，特别是在可能由目前被困在永久冻土层中的古代细菌释放引起的潜在爆发中。现有的商业消毒剂存在碳足迹高的问题。本研究提出了一种可持续的替代品，即一种由水热液化制备的生物质衍生的生物液体。研究结果表明，所制备的生物液体对致病性病毒和细菌具有很高的灭活率，例如对 H1N1、H5N1、H7N9 流感 A 病毒的灭活率高达 99.99%，对炭疽孢子和枯草芽孢杆菌的灭活率高达 99.49%。研究证实，生物液体中的低分子量和低极性化合物是潜在的抗菌成分。高温通过解聚和脱水反应促进了抗菌物质的产生。此外，兔皮试验证实生物液体是无毒的，每公斤生物液体的成本为 0.04427 美元，明显低于商业消毒剂。本研究表明，生物质具有支持我们生物安全的潜力，同时具有更高的环境可持续性。
