Department of Neurology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Department of Neurology, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Republic of Korea.
Sci Rep. 2022 Jan 10;12(1):426. doi: 10.1038/s41598-021-04250-3.
Visual aura (VA) presents in 98% of cases of migraine with aura. However, data on its prevalence and impact in individuals with migraine and probable migraine (PM) are limited. Data from the nation-wide, population-based Circannual Change in Headache and Sleep Study were collected. Participants with VA rating scale scores ≥ 3 were classified as having VA. Of 3,030 participants, 170 (5.6%) and 337 (11.1%) had migraine and PM, respectively; VA prevalence did not differ between these cohorts (29.4% [50/170] vs. 24.3% [82/337], p = 0.219). Participants with migraine with VA had a higher headache frequency per month (4.0 [2.0-10.0] vs. 2.0 [1.0-4.8], p = 0.014) and more severe cutaneous allodynia (12-item Allodynia Symptom Checklist score; 3.0 [1.0-8.0] vs. 2.0 [0.0-4.8], p = 0.046) than those without VA. Participants with PM with VA had a higher headache frequency per month (2.0 [2.0-8.0] vs. 2.0 [0.6-4.0], p = 0.001), greater disability (Migraine Disability Assessment score; 10.0 [5.0-26.3] vs. 5.0 [2.0-12.0], p < 0.001), and more severe cutaneous allodynia (12-item Allodynia Symptom Checklist score, 2.5 [0.0-6.0] vs. 0.0 [0.0-3.0], p < 0.001) than those without VA. VA prevalence was similar between migraine and PM. Some symptoms were more severe in the presence of VA.
视觉先兆（VA）出现在 98%的有先兆偏头痛病例中。然而，偏头痛和可能偏头痛（PM）个体中视觉先兆的患病率和影响的数据有限。全国性的基于人群的头痛和睡眠节律变化研究收集了数据。VA 评分量表得分≥3 的参与者被归类为有 VA。在 3030 名参与者中，分别有 170 名（5.6%）和 337 名（11.1%）患有偏头痛和 PM；这些队列之间 VA 的患病率没有差异（29.4%[50/170]与 24.3%[82/337]，p=0.219）。有偏头痛伴 VA 的参与者每月头痛发作频率更高（4.0[2.0-10.0]与 2.0[1.0-4.8]，p=0.014），皮肤感觉过敏更严重（12 项感觉过敏症状检查表评分；3.0[1.0-8.0]与 2.0[0.0-4.8]，p=0.046）。有 PM 伴 VA 的参与者每月头痛发作频率更高（2.0[2.0-8.0]与 2.0[0.6-4.0]，p=0.001），残疾程度更高（偏头痛残疾评估量表评分；10.0[5.0-26.3]与 5.0[2.0-12.0]，p<0.001），皮肤感觉过敏更严重（12 项感觉过敏症状检查表评分，2.5[0.0-6.0]与 0.0[0.0-3.0]，p<0.001）。偏头痛和 PM 之间 VA 的患病率相似。一些症状在有 VA 时更严重。
