Urology Institute, University Hospitals Cleveland Medical Center. Case Western Reserve University School of Medicine, Cleveland, OH, USA.
University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Int J Impot Res. 2022 Nov;34(7):679-684. doi: 10.1038/s41443-021-00513-9. Epub 2022 Jan 11.
Testosterone deficiency is known to affect men with increasing incidence throughout their lifespan. The clinical manifestations of testosterone deficiency, in turn, negatively impact men's quality of life and perception of overall health. The interaction of chronic systemic disease and androgen deficiency represent an area for potential intervention. Here, we explore the topic of testosterone deficiency amongst men with end-stage organ failure requiring transplantation in order to elucidate the underlying pathophysiology of androgen deficiency of chronic disease and discuss whether intervention, including testosterone replacement and organ transplantation, improve patients' outcomes and quality of life.
睾酮缺乏症的发病率随着男性年龄的增长而增加，这是众所周知的。反过来，睾酮缺乏症的临床表现会对男性的生活质量和整体健康感知产生负面影响。慢性系统性疾病和雄激素缺乏的相互作用代表了一个潜在的干预领域。在这里，我们探讨了终末期器官衰竭需要移植的男性中睾酮缺乏症的问题，以便阐明慢性疾病雄激素缺乏的潜在病理生理学，并讨论是否包括睾酮替代和器官移植在内的干预措施可以改善患者的结局和生活质量。
