Institute of Medical Microbiology and Hospital Hygiene, Philipps-University Marburg, Marburg, Germany.
Deutsches Rheumaforschungszentrum Berlin, Leibniz Institute, Berlin, Germany.
Nat Microbiol. 2022 Feb;7(2):195-199. doi: 10.1038/s41564-021-01046-z. Epub 2022 Jan 10.
Here we compared SARS-CoV-2-specific antibody and T-cell responses between older adults (>80 years old, n = 51) and a younger control group (20-53 years old, n = 46) after receiving two doses of BNT162b2. We found that responses in older adults were generally lower, and we identified 10% low-/non-responders. After receiving a third vaccination with BNT162b2, 4 out of 5 low-/non-responders showed antibody and T-cell responses similar to those of responders after two vaccinations.
在这里，我们比较了接种两剂 BNT162b2 后，老年人（>80 岁，n=51）和年轻对照组（20-53 岁，n=46）的 SARS-CoV-2 特异性抗体和 T 细胞反应。我们发现老年人的反应通常较低，并且我们确定了 10%的低/无反应者。接种第三剂 BNT162b2 后，5 名低/无反应者中的 4 名在接种两剂后表现出与应答者相似的抗体和 T 细胞反应。
