Sievers Benjamin L, Altaf Mazharul, Cheng Mark T K, Kamelian Kimia, Cormie Claire, Doffinger Rainer, Gupta Ravindra K
Department of Medicine, University of Cambridge, Cambridge, UK.
Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
NPJ Vaccines. 2025 Jul 1;10(1):132. doi: 10.1038/s41541-025-01196-9.
We investigated age-associated effects of SARS-CoV-2 vaccination in elderly individuals (n = 50, mean age 79) after six SARS-CoV-2 vaccine doses. While neutralization titers remained comparable across age groups, Fc-mediated effector functions declined with age. Individuals >80 demonstrated reduced antibody-dependent cellular cytotoxicity (ADCC), via a surrogate ADCC-signaling assay, correlating with diminished IgG1 binding. These findings highlight age-related impairments in Fc-mediated responses, with implications for immune protection and vaccine strategies in older populations.
我们研究了在接种六剂严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗后，老年个体（n = 50，平均年龄79岁）中与年龄相关的SARS-CoV-2疫苗接种效果。虽然中和滴度在各年龄组中保持相当，但Fc介导的效应功能随年龄下降。通过替代ADCC信号检测法，80岁以上个体的抗体依赖性细胞毒性（ADCC）降低，这与IgG1结合减少相关。这些发现突出了Fc介导反应中与年龄相关的损伤，对老年人群的免疫保护和疫苗策略具有启示意义。
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