School of Chemistry and Chemical Engineering, Anhui Key Laboratory of Modern Biomanufacturing, Anhui University, Hefei 230601, P. R. China.
Catholic University of Brasília, Brasília, Distrito Federal 70790-160, Brazil.
ACS Appl Bio Mater. 2021 Mar 15;4(3):2798-2809. doi: 10.1021/acsabm.1c00030. Epub 2021 Mar 4.
A single-atom metal doped on carbonaceous nanomaterials has attracted increasing attention due to its potential applications as high-performance catalysts. However, few studies focus on the applications of such nanomaterials as nanotheranostics for simultaneous bioimaging and cancer therapy. Herein, it is pioneeringly demonstrated that the single-atom Gd anchored onto graphene quantum dots (SAGd-GQDs), with dendrite-like morphology, was successfully prepared. More importantly, the as-fabricated SAGd-GQDs exhibits a robustly enhanced longitudinal relaxivity ( = 86.08 mM s) at a low Gd concentration of 2 μmol kg, which is 25 times higher than the commercial Gd-DTPA ( = 3.44 mM s). and studies suggest that the obtained SAGd-GQDs is a highly potent and contrast agent to obtain high-definition MRI, thereby opening up more opportunities for future precise clinical theranostics.
单原子金属掺杂碳纳米材料由于其在高性能催化剂方面的潜在应用而引起了越来越多的关注。然而，很少有研究关注此类纳米材料作为纳米诊疗剂在同时进行生物成像和癌症治疗方面的应用。在此，首次证明了单原子钆锚定在石墨烯量子点（SAGd-GQDs）上，具有树枝状形态，可以成功制备。更重要的是，所制备的 SAGd-GQDs 在低 Gd 浓度为 2 μmol kg 时表现出增强的纵向弛豫率（ = 86.08 mM s），是商业 Gd-DTPA（ = 3.44 mM s）的 25 倍。 和 研究表明，所获得的 SAGd-GQDs 是一种高效且对比度高的造影剂，可以获得高清晰度的 MRI，从而为未来的精确临床治疗开辟了更多机会。
