Eye Center, Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou 310009, China.
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
ACS Appl Bio Mater. 2021 Apr 19;4(4):3579-3586. doi: 10.1021/acsabm.1c00089. Epub 2021 Mar 19.
Phacoemulsification with implantation of intraocular lens (IOLs) has been widely applied as a standard treatment for cataract, which is the leading cause of vision impairment. However, it still remains a critical challenge to prevent posterior capsule opacification (PCO) in terms of postoperative visual quality. Herein, we report IOLs with mussel-inspired coatings for inhibiting lens epithelial cells and then preventing PCO through photothermal conversion effect. The mussel-inspired coatings are deposited on the nonoptical surface areas of IOLs, endowing the modified IOLs with efficient photothermal conversion property. The temperature can be facilely raised to 50-60 °C for the photothermal IOLs (PT-IOLs) by near-infrared (NIR) laser irradiation at a safe intensity of 0.3 W/cm. These PT-IOLs display high capability of inhibiting lens epithelial cells (LECs) . Therefore, under routine NIR laser irradiation, New Zealand white rabbits implanted with the PT-IOLs demonstrate significantly lower evaluation of PCO (EPCO) scores than the control groups. The overall results indicate that our PT-IOLs provide a promising choice for the clinical prevention of PCO, thus opening a way to maintain the postoperative visual qualities for cataract patients.
超声乳化白内障吸除术联合人工晶状体（IOL）植入已广泛应用于白内障的标准治疗，白内障是导致视力损害的主要原因。然而，如何在术后保持良好的视觉质量方面，预防后囊膜混浊（PCO）仍然是一个极具挑战性的问题。在此，我们报告了一种具有贻贝类启发涂层的 IOL，它可以通过光热转换效应抑制晶状体上皮细胞，从而预防 PCO。贻贝类启发涂层沉积在 IOL 的非光学表面区域，使改性 IOL 具有高效的光热转换特性。通过近红外（NIR）激光在安全强度为 0.3 W/cm 的照射下，光热 IOL（PT-IOL）的温度可轻易升高至 50-60°C。这些 PT-IOL 显示出抑制晶状体上皮细胞（LECs）的高能力。因此，在常规 NIR 激光照射下，植入 PT-IOL 的新西兰白兔的 PCO（EPCO）评分明显低于对照组。总体结果表明，我们的 PT-IOL 为临床预防 PCO 提供了一种有前途的选择，从而为白内障患者保持术后视觉质量开辟了道路。
