Center for Veterinary Dentistry and Oral Surgery, Gaithersburg, MD, USA.
Animal Dentistry & Oral Surgery, Leesburg, VA, USA.
J Vet Dent. 2021 Dec;38(4):193-198. doi: 10.1177/08987564211072396. Epub 2022 Jan 11.
Medical records were searched for dogs that had received curative intent surgery for oral malignant melanoma and ipsilateral excisional regional lymph node biopsy. Twenty-seven dogs were operated on and 25 dogs of these dogs met the inclusion criteria of signalment, post-excision margin status, presence of metastasis for each biopsied lymphocentrum, survival time post-excision, presence of recurrence or metastasis at follow-up or at death/euthanasia, location of the primary tumor, and any postoperative adjuvant treatment. These 25 dogs had complete tumor excision with tumor-free margins and 19 (76%) had postoperative adjuvant therapy. Median survival time after excision for the dogs in this study was 335.5 days. Results of this study support previous work that documents prolonged survival time following complete excision of oral malignant melanoma with tumor-free surgical margins in dogs. Additionally, 4 dogs (16%) had histologically confirmed regional lymph node metastasis at the time of definitive surgery.
检索了接受根治性手术治疗口腔恶性黑素瘤和同侧切除区域性淋巴结活检的狗的医疗记录。对 27 只狗进行了手术，其中 25 只狗符合以下纳入标准：品种、切除后边缘状态、每个切除的淋巴结中心的转移情况、切除后生存时间、随访或死亡/安乐死时的复发或转移情况、原发肿瘤的位置以及任何术后辅助治疗。这些 25 只狗均行完全肿瘤切除术，切缘无肿瘤，其中 19 只（76%）接受了术后辅助治疗。本研究中狗的切除后中位生存时间为 335.5 天。本研究的结果支持先前的研究工作，即对于手术切缘无肿瘤的口腔恶性黑素瘤狗，完全切除可延长生存时间。此外，4 只狗（16%）在明确手术时具有组织学证实的区域性淋巴结转移。
