Ron M, Menczel J, Schwartz L, Palti Z, Kidroni G
Department of Obstetrics and Gynecology, Hadassah University Hospital Mount Scopus, Jerusalem, Israel.
J Perinat Med. 1987;15(3):282-90. doi: 10.1515/jpme.1987.15.3.282.
The concentration of 25-hydroxyvitamin D3 (25(OH)D3), 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) were determined in amniotic fluid, fetal cord serum and maternal serum in 26 cases of elective cesarean sections at term. All the women had a normal pregnancy and did not get any vitamin D fortified preparations. The samples were collected during December 1982-April 1983, at 37-40 weeks of pregnancy. The respective levels (+/- S.D.) of 25(OH)D3, 24,25(OH)2D3 and 1,25(OH)2D3 in maternal serum were: 18.03 +/- 10.8 ng/ml, 1.473 +/- 1.562 ng/ml and 36 +/- 21.5 pg/ml; in fetal cord serum: 13.15 +/- 8.3 ng/ml, 0.9 +/- 0.76 ng/ml and 29.2 +/- 18.55 pg/ml and in amniotic fluid: 0.732 +/- 0.508 ng/ml, 0.212 +/- 0.104 ng/ml and 14.3 +/- 10.0 pg/ml. The levels of the three metabolites in maternal and fetal cord serum were not statistically different. There was a statistically significant correlation between maternal and fetal serum levels of 25(OH)D3 and 24,25(OH)2D3 (r = 0.79, p less than 0.01 and r = 0.743, p less than 0.01 respectively). No significant correlation was found in 1,25(OH)2D3 levels between maternal and fetal cord sera. This lack of correlation may well be in agreement with the recent findings of Kouppala, et al. who demonstrated that the fetus contributes to its own pool of 1,25(OH)2D3. A significant difference was found between maternal serum and amniotic fluid levels of the three metabolites. A statistically significant difference was also found between fetal serum levels of 25(OH)D3 and 24,25(OH)2D3 and amniotic fluid levels.(ABSTRACT TRUNCATED AT 250 WORDS)
测定了26例足月择期剖宫产孕妇羊水、胎儿脐血血清和母体血清中25-羟维生素D3（25(OH)D3）、24,25-二羟维生素D3（24,25(OH)2D3）和1,25-二羟维生素D3（1,25(OH)2D3）的浓度。所有孕妇妊娠均正常，未服用任何维生素D强化制剂。样本于1982年12月至1983年4月收集，妊娠37 - 40周。母体血清中25(OH)D3、24,25(OH)2D3和1,25(OH)2D3各自的水平（±标准差）分别为：18.03±10.8 ng/ml、1.473±1.562 ng/ml和36±21.5 pg/ml；胎儿脐血血清中：13.15±8.3 ng/ml、0.9±0.76 ng/ml和29.2±18.55 pg/ml；羊水中：0.732±0.508 ng/ml、0.212±0.104 ng/ml和14.3±10.0 pg/ml。母体和胎儿脐血血清中三种代谢物的水平无统计学差异。母体和胎儿血清中25(OH)D3和24,25(OH)2D3水平存在统计学显著相关性（r分别为0.79，p<0.01和r为0.743，p<0.01）。母体和胎儿脐血血清中1,25(OH)2D3水平未发现显著相关性。这种缺乏相关性可能与库帕拉等人最近的研究结果一致，他们证明胎儿自身可合成1,25(OH)2D3。母体血清和羊水三种代谢物水平存在显著差异。胎儿血清中25(OH)D3和24,25(OH)2D3水平与羊水水平也存在统计学显著差异。（摘要截短于250字）
