Janssens X, Veys E M, Verbruggen G, Declercq L
Department of Rheumatology, University of Ghent, Belgium.
J Rheumatol. 1988 Sep;15(9):1346-50.
Sensitivity and specificity of antiperinuclear factor (APF) determination were assessed in 127 patients with classical or definite rheumatoid arthritis (RA). The control population consisted of 262 patients with rheumatic complaints other than RA. Our results showed a sensitivity of 86.6%, a specificity of 96.2% and a Youden index of 82.8% for APF in RA. In 14.2% of the total population with RA the rheumatoid factor (RF) became negative in the course of the disease; all but one were found to be actually APF positive. Of the population with RA analyzed, 8.6% were consistently RF negative but APF positive. In view of its strong sensitivity and specificity for RA, APF determination is a valuable serological tool for the diagnosis of the disease. In APF positive, RF negative patients with RA the prognosis seems to be poor.
在127例典型或确诊类风湿关节炎（RA）患者中评估了抗核周因子（APF）检测的敏感性和特异性。对照人群包括262例患有除RA之外的风湿性疾病的患者。我们的结果显示，RA患者中APF的敏感性为86.6%，特异性为96.2%，约登指数为82.8%。在所有RA患者中，14.2%的患者类风湿因子（RF）在病程中转为阴性；除1例之外，其余均为APF阳性。在分析的RA患者人群中，8.6%始终为RF阴性但APF阳性。鉴于APF对RA具有较高的敏感性和特异性，APF检测是诊断该疾病的一种有价值的血清学工具。在APF阳性、RF阴性的RA患者中，预后似乎较差。
