Noritake D T, Weiner S R, Bassett L W, Paulus H E, Weisbart R
Department of Medicine, Sepulveda VAH, CA.
J Rheumatol. 1987 Oct;14(5):949-51.
Wegener's granulomatosis is a necrotizing granulomatous vasculitis with multisystem involvement. We reviewed the rheumatic manifestations among 50 patients with Wegener's granulomatosis. Arthralgia, myalgia and/or arthritis occurred in 2/3 of patients and 28% had nonerosive and nondeforming polyarthritis. Noninflammatory synovial fluid was found upon arthrocentesis of one patient with a knee effusion. Unexpected findings included soft tissue calcifications in 9 patients, sacroiliitis in 3, and relapsing polychondritis in 2. Rheumatoid factor was present in 1/2 of the patients tested. Additionally, both antinuclear antibodies and anti-DNA antibodies were detected in 14 and 38%, respectively, of patients tested.
韦格纳肉芽肿病是一种累及多系统的坏死性肉芽肿性血管炎。我们回顾了50例韦格纳肉芽肿病患者的风湿性表现。2/3的患者出现关节痛、肌痛和/或关节炎，28%的患者患有非侵蚀性、非变形性多关节炎。对1例膝关节积液患者进行关节穿刺时发现非炎性滑液。意外发现包括9例患者有软组织钙化，3例有骶髂关节炎，2例有复发性多软骨炎。1/2接受检测的患者存在类风湿因子。此外，分别有14%和38%接受检测的患者检测出抗核抗体和抗DNA抗体。
