Department of Chemical & Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409-1230, United States.
ACS Appl Bio Mater. 2022 Jan 17;5(1):265-271. doi: 10.1021/acsabm.1c01067. Epub 2021 Dec 27.
Metal-organic frameworks (MOFs) have been extensively used as drug delivery platforms because of their considerable textural properties and physiochemical tunability. However, most medicinal treatments often administer multiple therapeutic pharmaceuticals simultaneously and combined drug delivery over a single MOF carrier has not been extensively developed. As such, in this study we implemented Mg-MOF-74, which is known to have rapid pharmacokinetic properties, for the combined delivery of ibuprofen and curcumin to demonstrate the proof-of-concept for dual-drug delivery over this previously unexplored MOF. To this end, 30 wt % total drug loading of two drugs was impregnated at various ratios (25:5 ibuprofen-curcumin, 20:5 ibuprofen-curcumin, 15:15 ibuprofen-curcumin, 10:20 ibuprofen-curcumin, and 5:25 ibuprofen-curcumin), and the drug delivery performance of the materials was assessed from 0 to 24 h in phosphate-buffered saline (PBS) solution using high-performance liquid chromatography (HPLC). The experiments revealed that all five ratios of ibuprofen-curcumin loadings can effectively deliver both compounds; however, elevating the curcumin loading beyond 10 wt % decreases the drug loading efficiency for ibuprofen and can also inhibit ibuprofen release. Nevertheless, because Mg-MOF-74 was able to successfully deliver both compounds, this study serves as a promising proof-of-concept for dual-drug delivery from a single MOF carrier. In this regard, the work demonstrated herein expands the use of MOFs for drug delivery applications and can be used to supplement drug administration via orally ingested tablets.
金属-有机骨架（MOFs）由于其显著的结构特性和物理化学可调节性，已被广泛用作药物传递平台。然而，大多数医学治疗通常同时给予多种治疗药物，并且单一 MOF 载体的联合药物传递尚未得到广泛开发。因此，在这项研究中，我们使用了具有快速药代动力学特性的 Mg-MOF-74 来同时传递布洛芬和姜黄素，以证明在这种以前未探索的 MOF 上进行双重药物传递的概念验证。为此，将两种药物的总载药量为 30wt%的两种药物以不同比例（布洛芬-姜黄素 25:5、布洛芬-姜黄素 20:5、布洛芬-姜黄素 15:15、布洛芬-姜黄素 10:20 和布洛芬-姜黄素 5:25）浸渍，然后在磷酸盐缓冲盐水（PBS）溶液中使用高效液相色谱法（HPLC）从 0 到 24 小时评估材料的药物传递性能。实验表明，布洛芬-姜黄素负载的所有五个比例都能有效地传递两种化合物；然而，姜黄素的负载量超过 10wt%会降低布洛芬的载药效率，并且还会抑制布洛芬的释放。然而，由于 Mg-MOF-74 能够成功地传递两种化合物，因此该研究为从单一 MOF 载体进行双重药物传递提供了有前途的概念验证。在这方面，本文所展示的工作扩展了 MOFs 在药物传递应用中的使用，并可用于通过口服片剂补充药物管理。
