Lu Chongjiu, Ye Min, Long Lipeng, Zheng Yue, Liu Jiameng, Zhang Yue, Chen Zhengwang
Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi province, Gannan Normal University, Ganzhou 341000, China.
Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Hunan Normal University, Changsha 410081, China.
J Org Chem. 2022 Jan 21;87(2):1545-1553. doi: 10.1021/acs.joc.1c02498. Epub 2022 Jan 11.
An efficient formal alkenyl C-H cyanation reaction has been developed for the general synthesis of unsymmetrical diarylfumaronitriles in good to excellent yields. The reaction was achieved through tandem Michael addition and an oxidative process. The merits of this transformation include the use of KFe(CN) as a safe and nontoxic cyanide source, without an external noble metal catalyst, oxygen-involved reactions, easily available raw materials, good functional group tolerance, high stereoselectivity, and potential further application of the products.
已经开发出一种高效的正式烯基C-H氰化反应，用于一般合成不对称二芳基富马腈，产率良好至优异。该反应通过串联迈克尔加成和氧化过程实现。这种转化的优点包括使用KFe(CN)作为安全无毒的氰化物源，无需外部贵金属催化剂，涉及氧气的反应，原料容易获得，良好的官能团耐受性，高立体选择性以及产物的潜在进一步应用。
