儿童 COVID-19 感染后自身免疫性脑炎。
Pediatric Autoimmune Encephalitis Following COVID-19 Infection.
机构信息
Pediatrics, 23336Los Angeles County+USC Medical CenterLos Angeles, CA, USA.
Internal Medicine and Pediatrics, 23336Los Angeles County+USC Medical Center, Los Angeles, CA, USA.
出版信息
J Child Neurol. 2022 Mar;37(4):268-272. doi: 10.1177/08830738211069814. Epub 2022 Jan 11.
Abstract
Similar to the pathogenesis of autoimmune disease, SARS-CoV-2 (COVID-19) infection has been shown to be associated with dysregulated and persistent inflammatory reactions and production of some antibodies. We report 3 pediatric patients found to have serum SARS-CoV-2 antibodies who presented with neurologic findings suggestive of postinfectious autoimmune-mediated encephalitis. All 3 cases showed lymphocytic pleocytosis on cerebrospinal fluid studies and marked improvement in neurologic symptoms after high-dose intravenous corticosteroids. The manifestations of SARS-CoV-2 infection in the pediatric population are still an evolving area of study, and these cases suggest autoimmune-mediated encephalitis as yet another SARS-CoV-2 related complication.
摘要
类似于自身免疫性疾病的发病机制，SARS-CoV-2（COVID-19）感染已被证明与失调和持续的炎症反应以及某些抗体的产生有关。我们报告了 3 例发现血清 SARS-CoV-2 抗体的儿科患者，他们表现出提示感染后自身免疫性介导脑炎的神经系统表现。所有 3 例患者的脑脊液研究均显示淋巴细胞增多，并在大剂量静脉用皮质类固醇治疗后神经系统症状明显改善。SARS-CoV-2 感染在儿科人群中的表现仍是一个不断发展的研究领域，这些病例提示自身免疫性介导脑炎是 SARS-CoV-2 的另一种相关并发症。
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