谵妄和亚综合征谵妄与缺血性中风后长期死亡风险相关。
Delirium and subsyndromal delirium are associated with the long-term risk of death after ischaemic stroke.
机构信息
Department of Neurology, Jagiellonian University Medical College, ul. Botaniczna 3, 31-503, Kraków, Poland.
出版信息
Aging Clin Exp Res. 2022 Jun;34(6):1459-1462. doi: 10.1007/s40520-021-02071-y. Epub 2022 Jan 11.
BACKGROUND
Post-stroke delirium has a negative impact on functional outcome. We explored if there is any association between delirium, subsyndromal delirium and long-term mortality after ischaemic stroke and transient ischaemic attack.
METHODS
We included 564 patients with ischaemic stroke or transient ischaemic attack. We assessed symptoms of delirium during the first 7 days after admission. We used Cox proportional hazards models to analyse all-cause mortality during the first 5 years after stroke.
RESULTS
We diagnosed delirium in 23.4% and subsyndromal delirium in 10.3% of patients. During the follow-up, 72.7% of patients with delirium, 51.7% of patients with subsyndromal delirium and 22.7% of patients without delirious symptoms died (P < 0.001). Patients with subsyndromal delirium and delirium had higher risk of death in the multivariate analysis (HR 1.72, 95% CI 1.11-2.68, P = 0.016 and HR 3.30, 95% CI 2.29-4.76, P < 0.001, respectively).
CONCLUSIONS
Post-stroke delirium is associated with long-term mortality. Patients with subsyndromal delirium are at the intermediate risk of death.
背景
中风后谵妄对功能结局有负面影响。我们探讨了谵妄、亚综合征谵妄与缺血性中风和短暂性脑缺血发作后长期死亡率之间是否存在关联。
方法
我们纳入了 564 例缺血性中风或短暂性脑缺血发作患者。我们在入院后第 1 天至第 7 天评估谵妄症状。我们使用 Cox 比例风险模型分析中风后 5 年内的全因死亡率。
结果
我们诊断出 23.4%的患者存在谵妄，10.3%的患者存在亚综合征谵妄。在随访期间，72.7%的谵妄患者、51.7%的亚综合征谵妄患者和 22.7%的无谵妄症状患者死亡（P<0.001）。在多变量分析中，亚综合征谵妄和谵妄患者的死亡风险更高（HR 1.72，95%CI 1.11-2.68，P=0.016 和 HR 3.30，95%CI 2.29-4.76，P<0.001）。
结论
中风后谵妄与长期死亡率相关。亚综合征谵妄患者的死亡风险处于中等水平。
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