Bandim Health Project, OPEN, Department of Clinical Research, Odense University Hospital, University of Southern Denmark, Denmark; Danish Institute of Advanced Science, University of Southern Denmark, Denmark; Bandim Health Project, Indepth Network, Apartado 861, Bissau, Guinea-Bissau.
Bandim Health Project, Indepth Network, Apartado 861, Bissau, Guinea-Bissau.
Public Health. 2022 Feb;203:19-22. doi: 10.1016/j.puhe.2021.11.013. Epub 2021 Dec 3.
Many African countries have reported fewer COVID-19 cases than countries elsewhere. By the end of 2020, Guinea-Bissau, West Africa, had <2500 PCR-confirmed cases corresponding to 0.1% of the ∼1.8 million national population. We assessed the prevalence of SARS-CoV-2 antibodies in urban Guinea-Bissau to help guide the pandemic response in Guinea-Bissau.
Cross-sectional assessment of SARS-CoV-2 antibody in a cohort of staff at the Bandim Health Project.
We measured IgG antibodies using point-of-care rapid tests among 140 staff and associates at a biometric research field station in Bissau, the capital of Guinea-Bissau, during November 2020.
Of 140 participants, 25 (18%) were IgG-positive. Among IgG-positives, 12 (48%) reported an episode of illness since the onset of the pandemic. Twenty-five (18%) participants had been PCR-tested between May and September; 7 (28%) had been PCR-positive. Four of these seven tested IgG-negative in the present study. Five participants reported that somebody had died in their house, corresponding crudely to an annual death rate of 4.5/1000 people; no death was attributed to COVID-19. Outdoor workers had a lower prevalence of IgG-positivity.
In spite of the low official number of COVID-19 cases, our serosurvey found a high prevalence of IgG-positivity. Most IgG-positives had not been ill. The official number of PCR-confirmed COVID-19 cases has thus grossly underestimated the prevalence of COVID-19 during the pandemic. The observed overall mortality rate in households of Bandim Health Project employees was not higher than the official Guinean mortality rate of 9.6/1000 people.
许多非洲国家报告的 COVID-19 病例比其他国家少。到 2020 年底，西非的几内亚比绍有<2500 例经 PCR 确诊的病例，约占该国 180 万人口的 0.1%。我们评估了城市几内亚比绍中 SARS-CoV-2 抗体的流行情况，以帮助指导该国的大流行应对。
对班迪姆健康项目的工作人员进行 SARS-CoV-2 抗体的横断面评估。
我们于 2020 年 11 月在几内亚比绍首都比绍的一个生物计量研究野外站对 140 名工作人员和同事使用即时检测快速检测 IgG 抗体。
在 140 名参与者中，有 25 人（18%）IgG 阳性。在 IgG 阳性者中，有 12 人（48%）自大流行开始以来有过疾病发作。25 名参与者中有 25 名（18%）在 5 月至 9 月期间接受过 PCR 检测；7 人（28%）PCR 检测呈阳性。在本研究中，这 7 人中有 4 人 IgG 检测呈阴性。5 名参与者报告说有人在他们的房子里死亡，粗略地相当于每年 4.5/1000 人的死亡率；没有死亡归因于 COVID-19。户外工作者 IgG 阳性率较低。
尽管官方 COVID-19 病例数量较低，但我们的血清学调查发现 IgG 阳性率很高。大多数 IgG 阳性者并未患病。官方的 COVID-19 PCR 确诊病例数因此大大低估了大流行期间 COVID-19 的流行情况。班迪姆健康项目员工家庭观察到的总体死亡率并不高于官方的几内亚 9.6/1000 人的死亡率。
