Li Peihong, Zhang Chunling, Li Rui, Qu Lijie, Dai Xueyan, Sui Yanlong, Hou Jiazi
Key Laboratory of Automobile Materials, Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130022, P.R. China.
ACS Appl Bio Mater. 2019 Jan 22;2(1):527-532. doi: 10.1021/acsabm.8b00698. Epub 2019 Jan 10.
Pluronic F127 is a thermosensitive polymer that has been extensively studied and utilized in biomedicine. To improve the gelation properties of F127, α-cyclodextrin was introduced by physical interactions, such as forming inclusion complexes, hydrogen bond self-assembly, and hydrophobic interactions, to prepare F127-α-CD hydrogels. This study explored the temperature-dependent sol-gel transition behavior, gelation mechanism, interior morphology, and controlled release of the anticancer drug 5-fluorouracil. Results showed that hydrogel could be obtained at 1.0%-8.0% weight content of F127. The cross-linking points in this system were PEO-α-CD microcrystalline region and micelle with poly(propylene oxide) as the core. The network inside F127-α-CD hydrogels made it stable and conducive for controlled release. Therefore, this hydrogel is a promising drug release system.
泊洛沙姆F127是一种热敏聚合物，已在生物医学领域得到广泛研究和应用。为改善F127的凝胶化性能，通过物理相互作用，如形成包合物、氢键自组装和疏水相互作用，引入α-环糊精以制备F127-α-CD水凝胶。本研究探讨了温度依赖性溶胶-凝胶转变行为、凝胶化机制、内部形态以及抗癌药物5-氟尿嘧啶的控释情况。结果表明，当F127的重量含量为1.0%-8.0%时可获得水凝胶。该体系中的交联点为PEO-α-CD微晶区和以聚环氧丙烷为核的胶束。F127-α-CD水凝胶内部的网络结构使其稳定且有利于控释。因此，这种水凝胶是一种很有前景的药物释放系统。
