School of Materials Science and Engineering, Jilin University, Changchun, 130022, P. R. China.
Soft Matter. 2021 Apr 7;17(13):3664-3671. doi: 10.1039/d1sm00151e. Epub 2021 Mar 5.
Graphene oxide (GO) is an ideal hydrogel material because of its water solubility, non-toxicity, and excellent mechanical properties. Here, we added GO to oligo(lysine)-modified F127 to prepare a series of FLGO composite hydrogels. The FLGO hydrogel was thermally induced, stable and injectable. And the content of GO would affect the sol-gel transition, rheological properties and glass transition temperature of the FLGO hydrogel. GO was connected to the matrix through electrostatic interactions and hydrogen bonds. The cross-linking effect of GO enhanced the FLGO hydrogel. We also studied the release properties of the FLGO hydrogel loaded with anticancer drug 5-fluorouracil. Compared with F127 hydrogel, the FLGO hydrogel showed a linear, slower and stable release pattern within one week. The release rate of FLGO hydrogel could be adjusted by the pH and it was faster under acidic conditions. Therefore, the FLGO hydrogel is expected to be used as a drug release system in the field of biomedicine.
氧化石墨烯（GO）由于其水溶性、无毒性和优异的机械性能，是一种理想的水凝胶材料。在这里，我们将 GO 添加到聚（赖氨酸）修饰的 F127 中，制备了一系列 FLGO 复合水凝胶。FLGO 水凝胶具有热诱导、稳定和可注射性。GO 的含量会影响 FLGO 水凝胶的溶胶-凝胶转变、流变性能和玻璃化转变温度。GO 通过静电相互作用和氢键与基质相连。GO 的交联效应增强了 FLGO 水凝胶。我们还研究了负载抗癌药物 5-氟尿嘧啶的 FLGO 水凝胶的释放性能。与 F127 水凝胶相比，FLGO 水凝胶在一周内表现出线性、更慢和更稳定的释放模式。FLGO 水凝胶的释放速率可以通过 pH 值进行调节，在酸性条件下释放更快。因此，FLGO 水凝胶有望在生物医学领域用作药物释放系统。
