Teng Yufei, Yu Marco, Wang Yi, Liu Xinxin, You Qisheng, Liu Wu
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, 1 Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, 17 Hougouhutong Street, Dongcheng District, Beijing, 100005, China.
Graefes Arch Clin Exp Ophthalmol. 2017 May;255(5):893-902. doi: 10.1007/s00417-017-3586-0. Epub 2017 Feb 24.
To investigate the choriocapillary circulation in the macular area for eyes with unilateral idiopathic macular hole (IMH) before and after vitrectomy using optical coherence tomography angiography (OCTA).
A prospective study of 25 patients with unilateral IMH who underwent vitrectomy and 30 age- and sex-matched healthy controls were recruited. Choriocapillary circulation was measured by OCTA to obtain two measurements: flow area and parafovea vessel density.
Flow area and parafovea vessel density of choriocapillaris in the macular area were significantly smaller and lower in IMH eyes than unaffected fellow eyes and healthy control eyes (p < 0.001), while no difference was found between unaffected fellow eyes and the healthy control eyes. One month after vitrectomy, the choriocapillary flow area and parafovea vessel density of IMH eyes significantly increased compared to the peroperative measurements (p < 0.001). Association analysis found that choriocapillary circulation measurements were negatively correlated with macular hole diameters in IMH eyes (p < 0.001), but was independent with best-corrected visual acuity (BCVA).
The macular choriocapillary flow area and parafovea vessel density in IMH eyes were lower than those of normal controls. In addition, the choriocapillary circulation was negatively correlated with macular hole diameter. Our findings suggested that choroidal circulation in the macular area might be affected by the intact structure of the fovea.
使用光学相干断层扫描血管造影（OCTA）研究单侧特发性黄斑裂孔（IMH）眼玻璃体切除术前和术后黄斑区脉络膜毛细血管循环情况。
招募了25例接受玻璃体切除术的单侧IMH患者和30例年龄及性别匹配的健康对照者进行前瞻性研究。通过OCTA测量脉络膜毛细血管循环以获得两项指标：血流面积和黄斑旁血管密度。
IMH眼黄斑区脉络膜毛细血管的血流面积和黄斑旁血管密度显著小于未受影响的对侧眼和健康对照眼（p < 0.001），而未受影响的对侧眼与健康对照眼之间未发现差异。玻璃体切除术后1个月，IMH眼的脉络膜毛细血管血流面积和黄斑旁血管密度与手术前测量值相比显著增加（p < 0.001）。关联分析发现，IMH眼中脉络膜毛细血管循环测量值与黄斑裂孔直径呈负相关（p < 0.001），但与最佳矫正视力（BCVA）无关。
IMH眼的黄斑脉络膜毛细血管血流面积和黄斑旁血管密度低于正常对照。此外，脉络膜毛细血管循环与黄斑裂孔直径呈负相关。我们的研究结果表明，黄斑区的脉络膜循环可能受中央凹完整结构的影响。
