使用新型VIDAS自动检测原型快速检测抗IFN-α2自身抗体。

Rapid Detection of Anti-IFN-α2 Autoantibodies Using a New Automated VIDAS Assay Prototype.

作者信息

Pons Sylvie, Generenaz Laurence, Gervais Adrian, Puel Anne, Bastard Paul, Renard Nathalie, Guyot Valerie, Vinit Cecile, Zheng Fei, Brengel-Pesce Karen, Saker Kahina, Richard Jean-Christophe, Mathian Alexis, Amoura Zahir, Dorgham Karim, Gorochov Guy, Casanova Jean-Laurent, Fleurie Aurore, Trouillet-Assant Sophie

机构信息

Joint Research Unit Civils Hospices of Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA.

出版信息

Eur J Immunol. 2025 Apr;55(4):e202451516. doi: 10.1002/eji.202451516.

DOI:10.1002/eji.202451516

PMID:40223598

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11995241/

Abstract

Autoantibodies neutralizing Type I interferons increase the risk of severe viral diseases and are linked to autoimmune conditions. The automated VIDAS assay is suitable for anti-IFN-α2 IgGs quantification, offering a swift, reliable, user-friendly, single test for clinical management.

摘要

中和I型干扰素的自身抗体增加了严重病毒性疾病的风险，并与自身免疫性疾病有关。自动化的VIDAS检测适用于抗IFN-α2 IgG的定量分析，为临床管理提供了一种快速、可靠、用户友好的单一检测方法。