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环境空气污染对过敏性鼻炎症状的影响:一项前瞻性随访研究。

The Impact of Ambient Air Pollution on Allergic Rhinitis Symptoms: A Prospective Follow-Up Study.

作者信息

Sun Wen, Ding Chan, Jiang Zhuoying, Zheng Xinliang, Jiang Jinlan, Xu Huadong

机构信息

School of Public Health, Hangzhou Medical College, 182 Tianmushan Road, Xihu District, Hangzhou 310013, China.

The Second School of Clinical Medicine, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou 310053, China.

出版信息

Toxics. 2024 Sep 11;12(9):663. doi: 10.3390/toxics12090663.

Abstract

Air pollution has become a serious public health problem and there is evidence that air pollution affects the incidence of allergic rhinitis. To further investigate the effect of ambient air pollutants on the severity of allergic rhinitis symptoms, a prospective follow-up study in patients with allergic rhinitis was conducted. A total of 167 allergic rhinitis patients with a mean age of 35.4 years, who were visiting the hospital, were enrolled. The daily symptom severity of allergic rhinitis and the concentrations of six air pollutants, including PM, PM, SO, CO, O and NO were collected through follow-up investigations. The impact of ambient air pollutants on symptom severity was assessed via multi-pollutant models. Among several typical ambient air pollutants, we observed correlations of allergic rhinitis symptoms with PM, PM, CO, SO and NO, whereas O showed no such correlation. Specifically, PM and PM were significantly associated with sneezing and nasal blockage. NO was significantly correlated with symptoms of rhinorrhea, itchy nose and itchy eyes. CO was significantly linked to sneezing and nasal blockage symptoms. These air pollutants not only had a direct impact on allergic rhinitis symptoms but also exhibited a lagging effect. This study indicates that short-term exposure to air pollutants is associated with exacerbation of nasal symptoms in patients with allergic rhinitis, leading to a decline in their quality of life.

摘要

空气污染已成为一个严重的公共卫生问题,并且有证据表明空气污染会影响过敏性鼻炎的发病率。为了进一步研究环境空气污染物对过敏性鼻炎症状严重程度的影响,对过敏性鼻炎患者进行了一项前瞻性随访研究。总共招募了167名平均年龄为35.4岁的前来医院就诊的过敏性鼻炎患者。通过随访调查收集了过敏性鼻炎的每日症状严重程度以及六种空气污染物(包括PM、PM、SO、CO、O和NO)的浓度。通过多污染物模型评估环境空气污染物对症状严重程度的影响。在几种典型的环境空气污染物中,我们观察到过敏性鼻炎症状与PM、PM、CO、SO和NO之间存在相关性,而O则未显示出这种相关性。具体而言,PM和PM与打喷嚏和鼻塞显著相关。NO与流涕、鼻痒和眼痒症状显著相关。CO与打喷嚏和鼻塞症状显著相关。这些空气污染物不仅对过敏性鼻炎症状有直接影响,还表现出滞后效应。这项研究表明,短期接触空气污染物与过敏性鼻炎患者鼻部症状加重有关,导致其生活质量下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe9b/11436010/18eec046432c/toxics-12-00663-g001.jpg

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