San Martin Peter, Aunhachoke Kobkul, Batac Maria Christina Filomena, Lodrono-Lim Kris, Kwanthitinan Chanida, Santoso Dicky, Fonseka Thanabalan, Nguyen Minh, Guzman-Holst Adriana
GSK Vaccines, 20 Avenue Fleming, 1300, Wavre, Belgium.
Phramongkutklao Hospital, Bangkok, Thailand.
Infect Dis Ther. 2023 Jun;12(6):1553-1578. doi: 10.1007/s40121-023-00822-0. Epub 2023 Jun 14.
Herpes zoster (HZ; i.e., shingles) is caused by the reactivation of varicella zoster virus leading to a painful dermatomal rash. An increasing trend in cases of HZ is evident worldwide; however, there is a lack of comprehensive reviews for Southeast Asian countries.
We performed a systematic literature review of articles published until May 2022 that reported HZ epidemiology, clinical management, and health economic data in six Southeast Asian countries: Indonesia, Malaysia, the Philippines, Singapore, Thailand, and Vietnam. Literature searches were conducted in Medline, Scopus, Embase, and gray literature. Articles written in English or local languages were considered for inclusion.
In total, 72 publications were included in the study; 22 were case studies and over 60% originated in Singapore and Thailand. Only two studies (data from Thailand) reported incidence of HZ. The proportion of patients reported with HZ was 0.68-0.7% among dermatology clinics, 0.14% at one emergency department (5.3% of dermatology cases) in Singapore, and 3% of admissions at another hospital in Singapore. Pain was the most common symptom associated with HZ, reported in 74.21-100% of patients. HZ complications were reported in 10.2-21.2% of patients, and the proportions with postherpetic neuralgia and HZ ophthalmicus were 6.3-50% and 4.98-28.57%, respectively. Additionally, there is a lack of comprehensive, up-to-date HZ economic data, with only six studies identified for the Philippines, Singapore, and Thailand.
Overall, there are limited data reporting incidence and prevalence of HZ in Southeast Asia at a national level. High rates of complications, symptoms, and abundance of case reports suggest substantial healthcare resource utilization for patients with HZ and highlight the need for further research in Southeast Asia assessing the societal impact.
带状疱疹（HZ；即蛇串疮）是由水痘-带状疱疹病毒重新激活引起的，会导致疼痛性皮节皮疹。全球范围内HZ病例呈上升趋势；然而，东南亚国家缺乏全面的综述。
我们对截至2022年5月发表的报告印度尼西亚、马来西亚、菲律宾、新加坡、泰国和越南这六个东南亚国家HZ流行病学、临床管理和卫生经济数据的文章进行了系统的文献综述。在Medline、Scopus、Embase和灰色文献中进行文献检索。纳入用英语或当地语言撰写的文章。
该研究共纳入72篇出版物；22篇为病例研究，超过60%来自新加坡和泰国。只有两项研究（泰国的数据）报告了HZ的发病率。皮肤科诊所报告的HZ患者比例为0.68 - 0.7% 在新加坡的一个急诊科为0.14%（占皮肤科病例的5.3%），在新加坡的另一家医院为入院患者的3%。疼痛是与HZ相关的最常见症状，74.21 - 100%的患者有报告。10.2 - 21.2%的患者报告有HZ并发症，带状疱疹后神经痛和眼部带状疱疹的比例分别为6.3 - 50%和4.98 - 28.57%。此外，缺乏全面、最新的HZ经济数据，菲律宾、新加坡和泰国仅确定了六项研究。
总体而言，东南亚国家层面报告HZ发病率和患病率的数据有限。并发症发生率高、症状多以及病例报告丰富表明HZ患者大量使用医疗资源，并突出了在东南亚进行进一步研究以评估社会影响的必要性。
